Publications

Hwang K, Vaknalli R, Addo-Osafo K, Vicente M, Vossel K. Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms. Frontiers in Aging Neuroscience 2022. In Press 

Ranasinghe KG, Verma P, Cai C, Xie X, Kudo K, Gao X, Lerner H, Mizuiri D, Strom A, Iaccarino L, La Joie R, Miller BL, Gorno-Tempini ML, Rankin KP, Jagust WJ,  Vossel K, Rabinovici GD, Raj A, Nagarajan SS. Altered excitatory and inhibitory neuronal subpopulation parameters are distinctly associated with tau and amyloid in Alzheimer’s disease. eLife 2022. doi.org/10.7554/eLife.77850

Oh JY, Walsh CM, Ranasinghe K, Mladinov M, Pereira FL, Petersen C, Falgàs N, Ruoff L, Lamore T, Nasar R, Lew C, Li S, Metzler T, Coppola Q, Pandher N, Le M, Heuer HW, Heinsen H, Spina S, Seeley WW, Kramer J, Rabinovici GD, Boxer AL, Miller BL, Vossel K, Neylan TC, Grinberg LT. Subcortical neuronal correlates of sleep in neurodegenerative diseases. JAMA Neurology 2022 Apr 4;e220429. doi.org/10.1001/jamaneurol.2022.0429

Ranasinghe KG, Kudo K, Hinkley L, Beagle AJ, Lerner H, Mizuiri D, Findlay A, Miller BL, Kramer JH, Gorno-Tempini ML, Rabinovici GD, Rankin KP, Garcia PA, Kirsch HE, Vossel K (co-senior author), Nagarajan SS (co-senior author). Neuronal synchrony abnormalities associated with subclinical epileptiform activity in patients with early onset Alzheimer’s disease. Brain 2021 Dec 17;awab442. doi: 10.1093/brain/awab442

Vossel K, Ranasinghe KG, Beagle AJ, et al. Effect of Levetiracetam on Cognition in Patients With Alzheimer Disease With and Without Epileptiform Activity: A Randomized Clinical Trial. JAMA Neurology 2021. doi:10.1001/jamaneurol.2021.3310. PMC8477304

Vossel K, Karageorgiou E. Editorial: Silent Seizures and Memory Loss in Alzheimer's Disease. Frontiers in Neurology 2021;12:648650. doi.org/10.3389/fneur.2021.648650. PMCID: PMC7982410

Ranasinghe KG, Petersen C, Kudo K, Mizuiri D, Rankin KP, Rabinovici GD, Seeley WW, Spina S, Miller BL, Vossel K, Grinberg LT, Nagarajan SS. Reduced synchrony in alpha oscillations during life predicts postmortem neurofibrillary tangle density in early-onset and atypical Alzheimer’s disease. Alzheimer's & Dementia 2021. doi.org/10.1002/alz.12349. PMCID: In Process

Castro M, Venkateswaran N, Peters S, K, Deyle DR, Bower M, Boeve BF, Vossel K. Early-onset behavioral variant frontotemporal dementia in patient with retrotransposed full-length transcript of Matrin-3 variant 5. Frontiers in Neurology, 2020. doi.org/10.3389/fneur.2020.600468

Johnson, EL, Krauss GL, Kucharska-Newton A, Albert MS, Brandt J, Walker KA, Yasar S, Knopman DS, Vossel K, Gottesman RF. Dementia in late-onset epilepsy: the Atherosclerosis Risk in Communities study. Neurology 2020, 95:e3248-e3256. doi: 10.1212/WNL.0000000000011080. PMCID: PMC7836657

Shields L, Li H, Nguyen K, Kim H, Doric Z, Gill TM, Haddad D, Vossel K, Calvert M, Nakamura K. Mitochondrial fission is a critical modulator of mutant APP-induced neural toxicity. Journal of Biological Chemistry 2021, 296:100469. doi: 10.1016/j.jbc.2021.100469. PMCID: PMC8042169

Peters ST, Fahrenkopf A, Choquette JM, Vermilyea S, Lee MK, Vossel K. Ablating tau reduces hyperexcitability and moderates electroencephalographic slowing in transgenic mice expressing A53T human α-synuclein. Frontiers in Neurology 2020, 11:563. doi: 10.3389/fneur.2020.00563. PMCID: PMC7316964

Borghesani V, Hinkley LB, Ranasinghe KG, Thompson MMC, Shwe W, Mizuiri D, Lauricella M, Europa E, Honma S, Miller Z, Miller B, Vossel K, Houde JF, Gorno-Tempini ML, Nagarajan SS. Taking the sub-lexical route: brain dynamics of reading in the semantic variant of Primary Progressive Aphasia. Brain 2020 143:2545-2560. doi: 10.1093/brain/awaa212. PMCID: PMC7447517

Ranasinghe KG, Cha J, Hinkley LB, Beagle AJ, Jagust W, Miller BL, Rankin KP, Rabinovici GD, Vossel KA (co-senior author), Nagarajan SS (co-senior author). Neurophysiological signatures in Alzheimer’s disease are distinctly associated with tau, amyloid-beta accumulation, and cognitive decline. Science Translational Medicine 2020. doi: 10.1126/scitranslmed.aaz4069. PMCID: PMC7138514

Gamache J, Kemper L, Steuer E, Leinonen K, Choquette J, Hlynialuk C, Benzow K, Vossel KA, Xia W, Koob M, Ashe KH. Developmental pathogenicity of 4-repeat human tau is lost with the P301L mutation in genetically 1 matched tau-transgenic mice. Journal of Neuroscience 2019, 40:220-236. doi:10.1523/JNEUROSCI.1256- 19.2019. PMCID: PMC6939485

Ranasinghe KG, Kothare H, Kort N, Hinkley LB, Beagle AJ, Mizuiri D, Honma SM, Lee R, Miller BL, Gorno-Tempini ML, Vossel KA, Houde JF, Nagarajan SS. Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer’s disease. Scientific Reports 2019, 9:5686. doi:10.1038/s41598-019-41794-x. PMCID: PMC6450891

La AL, Walsh CM, Neylan TC, Vossel KA, Yaffe K, Krystal AD, Miller BL, Karageorgiou E. Long-term trazodone use and cognition: a potential therapeutic role for slow-wave sleep enhancers. Journal of Alzheimer’s Disease 2019, 67:911-921. doi: 10.3233/JAD-181145. PMCID: PMC6398835

Zeman A, Byruck M, Tallis P, Vossel K, Tranel D. Touching the void - first and third person perspectives in two cases of autobiographical amnesia linked to epilepsy. Neuropsychologia 2018, 110:55-64. doi: 10.1016/j.neuropsychologia.2017.07.007.

Lutsey PL, Chen N, Lakshminarayan K, Gottesman RF, Mosley TH, Knopman DS, Vossel KA, Mirabelli MC, Alonso A. Impaired lung function, lung disease and risk of incident dementia. American Journal of Respiratory and Critical Care Medicine 2018 Nov 15. doi: 10.1164/rccm.201807-1220OC. PMCID: PMC6543713

Vossel KA, Tartaglia MC, Nygaard HB, Zeman AZ, Miller BL. Epileptic activity in Alzheimer’s disease: causes and clinical relevance. The Lancet Neurology 2017, 16:311-322. doi: 10.1016/S1474-4422(17)30044-3. PMCID: PMC5973551

Beagle AJ, Darwish SM, Ranasinghe KG, La AL, Karageorgiou E, Vossel KA. Relative incidence of seizures and myoclonus in Alzheimer’s disease, dementia with Lewy bodies, and frontotemporal dementia. Journal of Alzheimer’s Disease 2017, 60:211-223. doi: 10.3233/JAD-170031. PMCID: PMC5608587

Karageorgiou E and Vossel KA. Brain rhythm attractor breakdown in Alzheimer’s disease: functional and pathological implications. Alzheimer's & Dementia 2017, 13:1054-1067. doi: 10.1016/j.jalz.2017.02.003. PMCID: PMC5585024

Perry DC, Brown J, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee S, Matthews BR, Kao AW, Vossel KA, Tartaglia MC, Miller ZA, Seo SW, Sidhu M, Gaus SE, Li AN, Vargas JN, Hwang J, Ossenkoppele R, Brown AB, Huang EJ, DeArmond SJ, Coppola G, Rosen HJ, Geschwind D, Trojanowski JQ, Grinberg LT, Kramer JH, Miller BL, Seeley WW. Clinicopathological correlations in behavioural variant frontotemporal dementia. Brain 2017, 140:3329-3345. doi: 10.1093/brain/awx254. PMCID: PMC5841140

Ranasinghe KG, Hinkley LB, Beagle AJ, Mizuiri D, Honma SM, Welch AE, Hubbard I, Mandelli ML, Miller ZA, Garrett C, La A, Boxer AL, Houde JF, Miller BL, Vossel KA, Gorno-Tempini ML, Nagarajan SS. Distinct patterns of resting state neural synchronizations in primary progressive aphasia variants. Brain 2017, 140:2737- 2751. doi: 10.1093/brain/awx217. PMCID: PMC5841154

Miyamoto T, Stein L, Taneja P, Djukic B, Knox J, Vossel K, Mucke L. Phosphorylation of tau at Y18, but not tau-Fyn binding, is required for tau to modulate NMDA receptor- dependent excitotoxicity in primary neuronal culture. Molecular Neurodegeneration 2017, 12:41. doi: 10.1186/s13024-017-0176-x. PMCID: PMC5438564

Ranasinghe KG, Gill JS, Kothare H, Beagle AJ, Mizuiri D, Honma SM, Gorno-Tempini ML, Miller BL, Vossel KA, Houde JF, Nagarajan SS. Abnormal vocal behavior predicts executive and memory deficits in Alzheimer’s disease. Neurobiology of Aging 2017, 52:71-80. doi: 10.1016/j.neurobiolaging.2016.12.020. PMCID: PMC5359035

Vossel KA, Ranasinghe KG, Beagle AJ, Mizuiri D, Honma SM, Dowling AF, Darwish SM, Barnes DE, Mantle M, Roberson ED, Miller BL, Garcia PA, Kirsch HE, Mucke L, Nagarajan SS. Incidence and impact of subclinical epileptiform activity in Alzheimer’s disease. Annals of Neurology 2016, 80:858-870. doi:10.1002/ana.24794. PMCID: PMC5177487

Ranasinghe KG, Rankin KP, Pressman PS, Perry DC, Lobach IV, Seeley WW, Coppola G, Karydas AM, Grinberg LT, Shany-Ur T, Lee SE, Rabinovici GD, Rosen HJ, Gorno-Tempini ML, Boxer AL, Miller ZA, Chiong W, DeMay M, Kramer JH, Possin KL, Sturm VE, Bettcher BM, Neylan M, Zackey DD, Nguyen LA, Ketelle R, Block N, Wu TQ, Dallich A, Russek N, Caplan A, Geschwind DH, Vossel KA, Miller BL. Distinct subtypes of behavioral-variant frontotemporal dementia based on patterns of network degeneration. JAMA Neurology 2016, 73:1078-1088. doi: 10.1001/jamaneurol.2016.2016. PMCID: PMC5024785

Ossenkoppele R, Schonhaut DR, Schöll M, Lockhart SN, Ayakta N, Lazaris A, Cantwell A, Vogel J, Baker SL, O’Neil JP, Janabi M, Santos M, Miller ZA, Bettcher BM, Vossel KA, Kramer JH, Gorno-Tempini ML, Miller BL, Jagust WJ, Rabinovici GD. Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease. Brain 2016, 139:1551-1567. doi: 10.1093/brain/aww027. PMCID: PMC5006248

Ranasinghe KG, Rankin KP, Lobach IV, Kramer JH, Sturm VE, Bettcher BM, Possin K, You SC, Lamarre AK, Shany-Ur T, Stephens ML, Perry DC, Lee SE, Miller ZA, Gorno-Tempini ML, Rosen HJ, Boxer A, Seeley WW, Rabinovici GD, Vossel KA, Miller BL. Cognition and neuropsychiatry in behavioral variant frontotemporal dementia by disease stage. Neurology 2016, 86:600-610. doi: 10.1212/WNL.0000000000002373. PMCID: PMC4762418

Morris M, Sanchez PE, Verret L, Beagle AJ, Guo W, Dubal D, Ranasinghe KG, Koyama A, Vossel KA, Mucke L. Neural network dysfunction in α-synuclein transgenic mice and human Lewy body dementia. Annals of Clinical and Translational Neurology 2015, 2:1012-1028. doi: 10.1002/acn3.257. PMCID: PMC4693622

Vossel KA, Xu JC, Fomenko V, Miyamoto T, Suberbielle E, Knox JA, Ho K, Yu G, Mucke L. Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β. The Journal of Cell Biology 2015, 209:419-433. doi: 10.1083/jcb.201407065. PMCID: PMC4427789

Ranasinghe KG, Hinkley LB, Beagle AJ, Mizuiri D, Dowling AF, Honma SM, Finucane MM, Scherling C, Miller BL, Nagarajan SS, Vossel KA. Regional functional connectivity predicts distinct cognitive impairments in Alzheimer's disease spectrum. NeuroImage Clinical 2014, 5:385–395.  doi: 10.1016/j.nicl.2014.07.006. PMCID: PMC4145532

Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, Hegde M, Cornes SB, Henry ML, Nelson AB, Seeley WW, Geschwind MD, Gorno-Tempini ML, Shih T, Kirsch HE, Garcia PA, Miller BL, Mucke L. Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurology 2013, 70:1158-66. doi: 10.1001/jamaneurol.2013.136. PMCID: PMC4013391

Vossel KA, Bien-Ly N, Bernardo A, Rascovsky K, Karydas A, Rabinovici GD, Sidhu M, Huang EJ, Miller BL, Huang Y, Seeley WW. ApoE4 and TDP-43 neuropathology in two siblings with familial FTLD-motor neuron disease. Neurocase 2013, 19:295- 301. doi: 10.1080/13554794.2012.667124. PMCID: PMC3655113

Sanchez PE, Zhu L, Verret L, Vossel KA, Orr AG, Cirrito JR, Devidze N, Yu G, Palop JJ, Mucke L. Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease mouse model. Proceedings of the National Academy of Sciences U.S.A. 2012, 109:E2895-2903. doi: 10.1073/pnas.1121081109. PMCID: PMC3479491

Morris M, Maeda S, Vossel K, Mucke L. The many faces of tau. Neuron 2011, 70:410-26. doi: 10.1016/j.neuron.2011.04.009. PMCID: PMC3319390

Vossel KA, Zhang K, Brodbeck J, Daub AC, Sharma P, Finkbeiner S, Cui B, Mucke L. Tau reduction prevents Aβ-induced defects in axonal transport. Science 2010, 330:198. doi: 10.1126/science.1194653. PMCID: PMC3024010

Agosta F (co-first author), Vossel KA (co-first author), Miller BL, Migliaccio R, Bonasera S, Boxer AL, Karydas A, Possin KL, Gorno-Tempini ML. Apolipoprotein E epsilon4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia. Proceedings of the National Academy of Sciences U.S.A. 2009, 106:2018-22. doi: 10.1073/pnas.0812697106. PMCID: PMC2644156

Vossel KA, Miller BL. New approaches to treatment of frontotemporal lobar degeneration. Current Opinion in Neurology 2008, 21:708–716. doi: 10.1097/WCO.0b013e328318444d. PMCID: PMC2744321