Determination of molecular signatures of immunopathogenesis of HIV-1 infection with an ultimate goal to understand end organ disease in chronic HIV-1 infection and develop therapies for clinical translation.
Our current work focuses on HIV-1 related inflammation, oxidative stress and immune dysfunction and development of novel antioxidant and anti-inflammatory therapeutic modalities for end organ disease and premature aging associated with chronic HIV-1 infection.
Cardiovascular and metabolic disease in HIV infected and uninfected persons.
Our research has contributed to understanding of how oxidative stress, inflammation and immune dysfunction contribute to development of atherosclerotic cardiovascular disease (CVD) and metabolic disease in both HIV uninfected and infected persons.
Pathogenesis of SARS-CoV-2 infectioin.
Our current research focuses on how oxidative stress contributes to development of SARS-CoV-2 pathogenesis and end organ disease with a goal to develop novel antioxidant, anti-inflammatory and antiviral strategies for COVID-19.
