The Tontonoz Lab













 

Journal Club

The Tontonoz Lab administers a monthly “Molecular Metabolism” journal club dedicated to discussing cutting edge discoveries that impact metabolic research. Our group includes members of the following professors’ laboratories:

We meet on the third Monday of each month at 1pm in the MRL 6-740 seminar room. If you would like to join our mailing list, please send a request to Dr. Stephen Lee, or join our Google group

Papers Presented from October 16, 2015 Onward:

 

Date Presenter⠀⠀⠀⠀⠀⠀⠀⠀⠀ Journal⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀ Citation
9/16/19 Dr. Michael Shum
Liesa Lab
‌Cell Metabolism Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver
8/19/19 ‌Dr. John Kennelly
Tontonoz Lab
Nature SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis
‌7/15/19 ‌Dr. Hayato Muranaka
Bensinger Lab
‌Nature Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity
‌6/17/19 ‌Dr. Karthickeyan Krishnan
Lusis Lab
‌Cell Metabolism A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate
‌5/20/19 Dr. Leslie Sedgeman
Tarling/Vallim Lab
Cell

Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression

Supplement: 2019-05 Hancock et al Cell (from our google drive)

‌4/15/19 Dr. Ed Van Veen
Correa Lab
J. Clin. Invest.

Neuronal hypothalamic regulation of body metabolism and bone density is galanin dependent

Supplement: 2019-04 Idelevich et al JCI (from our google drive)

‌3/18/19 ‌Dr. Xu Xiao
Tontonoz Lab
‌Cell Metabolism

Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD+ Recycling

Supplement: 2019-03 Kim et al Cell Metabolism.pdf (from google drive)

‌2/25/19 ‌‌Dr. Huan Wang
Reue Lab
Cell

Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation

Supplement: 2019-02 Brandt et al Cell.pdf (from google drive)

‌1/28/19 ‌Dr. Prashant Rajbhandari
Tontonoz Lab
Nature Metabolism

The long noncoding RNA CHROME regulates cholesterol homeostasis in primates

Supplement: Hennessy et al Nature Met 2019.pdf (from google drive)

11/16/18 Dr. Bethan Clifford
Tarling/Vallim Lab
Cell Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes
10/19/18 Dr. Christina Priest
Tontonoz Lab
Cell Metabolism Acute and Repeated Treatment with 5-PAHSA or 9-PAHSA Isomers Does Not Improve Glucose Control in Mice
9/21/18 Dr. Michael Shum
Liesa Lab
Cell Metabolism The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase
8/17/18 Dr. Zhi Zhang
Correa Lab
Cell Reports A Neural Circuit Underlying the Generation of Hot Flushes
7/20/18 Alex Salisbury
Sallam Lab
Cell  The Inner Nuclear Membrane Is a Metabolically Active Territory that Generates Nuclear Lipid Droplets
6/15/18 Dr. Karthickeyan Krishnan
Lusis Lab
Nature Medicine The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis
5/18/18

Joan Cheng              Dr. Jenny Link
Tarling/Vallim Lab

Cell Metabolism Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism
4/20/18

‌Dr. Allison Chi
Bensinger Lab

Nature

Innate and Adaptive Lymphocytes Sequentially Shape the Gut Microbiota and Lipid Metabolism Link

3/16/18 ‌Dr. Alessandra Ferrari
Tontonoz Lab
Cell

Metabolic Induction of Trained Immunity through the Mevalonate Pathway

‌2/16/18

‌Karen Ong
Reue Lab

Cell Metabolism

System-wide Benefits of Intermeal Fasting by Autophagy

‌1/19/18 ‌Lara Bideyan
Tontonoz Lab
Cell

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis

‌11/17/17

‌Elinor Lee
Tarling/Vallim Lab

Cell Metabolism

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota

‌10/20/17

Dr. Zhengyi Zhang
Sallam Lab

Cell Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity
‌9/8/17 ‌Dr. Karthickeyan Krishnan
Lusis Lab
Cell Metabolism Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis
8/18/17‌ Kevin Qian
Tontonoz Lab
Cell Metabolism Long-Term Cold Adaptation Does Not Require FGF21 or UCP1
‌7/14/17

Dr. Jenny Link
Tarling/Vallim Lab

Nature Medicine Cold-Induced Conversion of Cholesterol to Bile Acids in Mice Shapes the Gut Microbiome and Promotes Adaptive Thermogenesis
‌6/23/17

Alex Salisbury
Tontonoz Lab

Nature Methods Unexpected Mutations After CRISPR–Cas9 Editing in Vivo
5/19/17‌

Dr. Stephen D. Lee
Tontonoz Lab

Nature Medicine ‌Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis
4/21/2017 ‌Dr. Wayne Hsieh
Bensinger Lab
PLoS Pathogens DENV up-regulates the HMG-CoA reductase activity through the impairment of AMPK phosphorylation: A potential antiviral target
‌3/17/17 Dr. Jie Gao
Tontonoz Lab
Nature Neurotoxic Reactive Astrocytes are Induced by Activated Microglia
2/17/17

Dr. Laurent Vergnes
Reue Lab

‌Nature Persistent microbiome alterations modulate the rate of post-dieting weight regain
1/20/17‌ ‌Dr. Marcus Tol
Tontonoz Lab
Cell ‌Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism
11/18/16‌ ‌Dr. Bo Wang
Tontonoz Lab
Nature Fatty Acid synthesis configures the plasma membrane for inflammation in diabetes‌
‌10/21/16

Dr. Bethan Clifford
Tarling/Vallim Lab

J. Clin. Invest. ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors‌
‌9/16/16 Jose L. Orozco
Tontonoz Lab
J. Biol. Chem Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation
‌8/19/16 ‌Dr. Li Zhang
Tontonoz Lab
Nature TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis
6/17/16

Albert Sek
Reue Lab

Cell The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia
‌5/20/16

‌Dr. Xin Rong
Tontonoz Lab

Cell Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts
‌4/15/16

‌Dylan Zhou and Joe Argus
Bensinger Lab

Dev. Cell Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells
‌3/18/16

‌Dr. Liz Tarling
Tarling/Vallim Lab

Science Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease‌
2/19/16‌

‌Dr. Prashant Rajbhandari
Tontonoz Lab

Nature Depletion of fat-resident Treg cells prevents age-associated insulin resistance
‌1/15/16

Dr. Jihane Benhammou
Beaven Lab

NEJM ‌FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
‌11/20/15

J‌aspreet Sandhu
Tontonoz Lab

Cell ‌Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis
10/16/15

Dr. Stephen D. Lee
Tontonoz Lab

Nature The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1