The Tontonoz Lab


Journal Club

The Tontonoz Lab administers a monthly “Molecular Metabolism” journal club dedicated to discussing cutting edge discoveries that impact metabolic research. Our group includes members of the following professors’ laboratories:

We meet on the third Monday of each month at 1pm in the MRL 6-740 seminar room. If you would like to join our mailing list, please send a request to Dr. Stephen Lee, or join our Google group

Papers Presented from October 16, 2015 Onward:


Date Presenter⠀⠀⠀⠀⠀⠀⠀⠀⠀ Journal⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀ Citation
11/18/19 ‌Dr. Xu Xiao
Tontonoz Lab
Cell Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
10/21/19 Dr. Irina Lapina
Sallam Lab
‌Cell Metabolism Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae
9/16/19 Dr. Michael Shum
Liesa Lab
‌Cell Metabolism Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver
8/19/19 ‌Dr. John Kennelly
Tontonoz Lab
Nature SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis
‌7/15/19 ‌Dr. Hayato Muranaka
Bensinger Lab
‌Nature Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity
‌6/17/19 ‌Dr. Karthickeyan Krishnan
Lusis Lab
‌Cell Metabolism A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate
‌5/20/19 Dr. Leslie Sedgeman
Tarling/Vallim Lab

Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression

Supplement: 2019-05 Hancock et al Cell (from our google drive)

‌4/15/19 Dr. Ed Van Veen
Correa Lab
J. Clin. Invest.

Neuronal hypothalamic regulation of body metabolism and bone density is galanin dependent

Supplement: 2019-04 Idelevich et al JCI (from our google drive)

‌3/18/19 ‌Dr. Xu Xiao
Tontonoz Lab
‌Cell Metabolism

Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD+ Recycling

Supplement: 2019-03 Kim et al Cell Metabolism.pdf (from google drive)

‌2/25/19 ‌‌Dr. Huan Wang
Reue Lab

Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation

Supplement: 2019-02 Brandt et al Cell.pdf (from google drive)

‌1/28/19 ‌Dr. Prashant Rajbhandari
Tontonoz Lab
Nature Metabolism

The long noncoding RNA CHROME regulates cholesterol homeostasis in primates

Supplement: Hennessy et al Nature Met 2019.pdf (from google drive)

11/16/18 Dr. Bethan Clifford
Tarling/Vallim Lab
Cell Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes
10/19/18 Dr. Christina Priest
Tontonoz Lab
Cell Metabolism Acute and Repeated Treatment with 5-PAHSA or 9-PAHSA Isomers Does Not Improve Glucose Control in Mice
9/21/18 Dr. Michael Shum
Liesa Lab
Cell Metabolism The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase
8/17/18 Dr. Zhi Zhang
Correa Lab
Cell Reports A Neural Circuit Underlying the Generation of Hot Flushes
7/20/18 Alex Salisbury
Sallam Lab
Cell  The Inner Nuclear Membrane Is a Metabolically Active Territory that Generates Nuclear Lipid Droplets
6/15/18 Dr. Karthickeyan Krishnan
Lusis Lab
Nature Medicine The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis

Joan Cheng              Dr. Jenny Link
Tarling/Vallim Lab

Cell Metabolism Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

‌Dr. Allison Chi
Bensinger Lab


Innate and Adaptive Lymphocytes Sequentially Shape the Gut Microbiota and Lipid Metabolism Link

3/16/18 ‌Dr. Alessandra Ferrari
Tontonoz Lab

Metabolic Induction of Trained Immunity through the Mevalonate Pathway


‌Karen Ong
Reue Lab

Cell Metabolism

System-wide Benefits of Intermeal Fasting by Autophagy

‌1/19/18 ‌Lara Bideyan
Tontonoz Lab

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis


‌Elinor Lee
Tarling/Vallim Lab

Cell Metabolism

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota


Dr. Zhengyi Zhang
Sallam Lab

Cell Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity
‌9/8/17 ‌Dr. Karthickeyan Krishnan
Lusis Lab
Cell Metabolism Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis
8/18/17‌ Kevin Qian
Tontonoz Lab
Cell Metabolism Long-Term Cold Adaptation Does Not Require FGF21 or UCP1

Dr. Jenny Link
Tarling/Vallim Lab

Nature Medicine Cold-Induced Conversion of Cholesterol to Bile Acids in Mice Shapes the Gut Microbiome and Promotes Adaptive Thermogenesis

Alex Salisbury
Tontonoz Lab

Nature Methods Unexpected Mutations After CRISPR–Cas9 Editing in Vivo

Dr. Stephen D. Lee
Tontonoz Lab

Nature Medicine ‌Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis
4/21/2017 ‌Dr. Wayne Hsieh
Bensinger Lab
PLoS Pathogens DENV up-regulates the HMG-CoA reductase activity through the impairment of AMPK phosphorylation: A potential antiviral target
‌3/17/17 Dr. Jie Gao
Tontonoz Lab
Nature Neurotoxic Reactive Astrocytes are Induced by Activated Microglia

Dr. Laurent Vergnes
Reue Lab

‌Nature Persistent microbiome alterations modulate the rate of post-dieting weight regain
1/20/17‌ ‌Dr. Marcus Tol
Tontonoz Lab
Cell ‌Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism
11/18/16‌ ‌Dr. Bo Wang
Tontonoz Lab
Nature Fatty Acid synthesis configures the plasma membrane for inflammation in diabetes‌

Dr. Bethan Clifford
Tarling/Vallim Lab

J. Clin. Invest. ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors‌
‌9/16/16 Jose L. Orozco
Tontonoz Lab
J. Biol. Chem Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation
‌8/19/16 ‌Dr. Li Zhang
Tontonoz Lab
Nature TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis

Albert Sek
Reue Lab

Cell The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia

‌Dr. Xin Rong
Tontonoz Lab

Cell Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts

‌Dylan Zhou and Joe Argus
Bensinger Lab

Dev. Cell Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

‌Dr. Liz Tarling
Tarling/Vallim Lab

Science Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease‌

‌Dr. Prashant Rajbhandari
Tontonoz Lab

Nature Depletion of fat-resident Treg cells prevents age-associated insulin resistance

Dr. Jihane Benhammou
Beaven Lab

NEJM ‌FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

J‌aspreet Sandhu
Tontonoz Lab

Cell ‌Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis

Dr. Stephen D. Lee
Tontonoz Lab

Nature The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1