Journal Club

The Tontonoz Lab administers a monthly “Molecular Metabolism” journal club dedicated to discussing cutting edge discoveries that impact metabolic research. Our group includes members of the following professors’ laboratories:

We meet on the third Monday of each month at 1pm. At the moment all seminars are zoom, not in the MRL 6-740 seminar room as it used to be. If you would like to join our mailing list, please send a request to Ingrid Gonzalez, or join our Google group

Papers Presented from October 16, 2015 Onward:

 

Date Presenter⠀⠀⠀⠀⠀⠀⠀⠀⠀ Journal⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀ Citation
‌6/27/2022 ‌Maykel Rodriguez ‌Nature

ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids

https://uclahs.zoom.us/j/5162941971?pwd=K3pHa1VDM3Vvb3BhSTVEV3ZSZk81QT09

‌5/16/2022

‌Alexander Nguyen

Tontonoz Lab

‌Nature

Regulation of liver subcellular architecture controls metabolic homeostasis

https://ucla.zoom.us/j/94973420231?pwd=YlFSR3hxcTN4OGt3dlBMVTkxOWxnQT09

‌4/18/2022

‌Liujuan Cui

Tontonoz Lab

‌Science

 Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP – dependent IL – 1 production

 

https://zoom.us/j/94440933636?pwd=KzdicjhlMDRYTSs2SmFuV2FiMjcxZz09

‌3/21/2022

‌Rohith Nagari

Tontonoz Lab

‌Nature

https://ucla.zoom.us/j/98851969208

8/16/21 Rozeta Avetisyan
Reue Lab
JCI

Hypothalamic REV-ERB nuclear receptors control diurnal food intake and leptin sensitivity in diet-induced obese mice

https://ucla.zoom.us/j/95998839213?pwd=RWR1bHZ4UTdoTGMvbmptSVh5b0NUUT09

7/19/21 Dr. Irina Lapina
Sallam Lab
Cell

Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis

https://uclahs.zoom.us/j/93058404844?pwd=WU9jM2o4NGtMSXBzK3BCajZNM1VEZz09

6/21/21 Dr. Kelsey Jarrett
Tarling/Vallim Lab
Cell Metabolism

TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis

https://uclahs.zoom.us/j/99381331788?pwd=WkoxYnR6TXFibWsyc21xUWtkZzNFUT09

5/17/21 Vincent Gutierrez
Liesa Lab
Nature Metabolism

Cellular pyrimidine imbalance triggers mitochondrial DNA-dependent innate immunity

https://uclahs.zoom.us/j/96311156160?pwd=aVZTUGdoQTFWMk9iRytuc0tOYndOZz09

4/19/21 Tim Moore
Lusis Lab
Cell Metabolism

Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health

https://uclahs.zoom.us/j/99719012991?pwd=T2pBK1pJb2dKaHJaUlViTmdpbVpMUT09

3/15/21 Kelly Kennewick
Bensinger Lab
Nature

Lipid signalling enforces functional specialization of Treg cells in tumours

https://ucla.zoom.us/j/94095039822?pwd=aVN3Y0VsSTBiYU1HTWVZZTJncUNsQT09

2/22/21 Lauren Uchiyama
Tontonoz Lab
Cell

NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

https://ucla.zoom.us/j/97924180793?pwd=S0xMQWh0NVZKN0FlaTBJMk15bG5mdz09

1/25/21 Mirian Krystel De Siqueira
Villanueva Lab
Cell Metabolism

Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus

https://ucla.zoom.us/j/94126729295?pwd=ZStVTGp0cjJFcmJlY0s4UVRyZFFUUT09

11/16/20 Vincent Gutierrez
Liesa Lab
Science

Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense

https://ucla.zoom.us/j/97495424498?pwd=MER4ZHVlYlVlaytQZHZsc3g3ZXQyUT09

10/19/20 Arthe Raajendiran
Villanueva Lab
Cell Metabolism

Ablation of Fat Cells in Adult Mice Induces Massive Bone Gain

https://ucla.zoom.us/j/4653200454

9/21/20 Dr. Karthickeyan Chella Krishnan
Lusis Lab
Cell Metabolism

"Serine Catabolism Feeds NADH when Respiration Is Impaired". He also wanted to share the preview for this article and the supplemental figures.

https://ucla.zoom.us/j/94555218596?pwd=bEhPUFp2S29LckZrd29XTWQ0bXNTdz09

8/17/20 Alex Bedard
Tontonoz Lab
Cell

CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling

Zoom: https://ucla.zoom.us/j/98587642103

7/20/20 Dr. Zhenqi Zhou
Hevener Lab
Nature

Treatment of type 2 diabetes with the designer cytokine IC7Fc

Zoom: https://ucla.zoom.us/j/4538074681

6/15/20 Dr. Dan Wang
Sallam Lab
Cell

Identification of ALK in Thinness

Zoom: https://uclahs.zoom.us/j/99401450774

5/18/20 Dr. Kelsey Jarrett
Tarling/Vallim Lab
Molecular Metabolism

Antisense oligonucleotide treatment produces a type I interferon response that protects against diet-induced obesity

Zoom: https://uclahs.zoom.us/j/99401450774

5/4/20 Min Sub and Ian Ford
Bensinger Lab
Nature

The gluconeogenic enzyme PCK1phosphorylates INSIG1/2 for lipogenesis

Zoom Meeting ID: 966 8798 9848 (password required to access seminar)

4/20/20 Dr. Megan Massa
Correa Lab
Cell Metabolism

Microglial UCP2 Mediates Inflammation and Obesity Induced by High-Fat Feeding

Zoom Meeting ID: 960 0264 1147 (password required to access seminar)

4/6/20 ‌Dr. Yajing Gao
Tontonoz Lab
Nature

Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate

Zoom link below:

https://uclahs.zoom.us/j/567576231

3/16/20 Dr. Zhenqi Zhou
Hevener Lab
CANCELLED DUE COVID-19 OUTBREAK
2/24/20 Dr. Carrie Wiese
Reue Lab
Cell Metabolism TAZ Is a Negative Regulator of PPARg Activity inAdipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance
1/20/20 ‌Dr. Yuta Shimanaka
Tontonoz Lab
Cell Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis
11/18/19 ‌Dr. Xu Xiao
Tontonoz Lab
Cell Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
10/21/19 Dr. Irina Lapina
Sallam Lab
‌Cell Metabolism Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae
9/16/19 Dr. Michael Shum
Liesa Lab
‌Cell Metabolism Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver
8/19/19 ‌Dr. John Kennelly
Tontonoz Lab
Nature SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis
‌7/15/19 ‌Dr. Hayato Muranaka
Bensinger Lab
‌Nature Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity
‌6/17/19 ‌Dr. Karthickeyan Krishnan
Lusis Lab
‌Cell Metabolism A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate
‌5/20/19 Dr. Leslie Sedgeman
Tarling/Vallim Lab
Cell

Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression

Supplement: 2019-05 Hancock et al Cell (from our google drive)

‌4/15/19 Dr. Ed Van Veen
Correa Lab
J. Clin. Invest.

Neuronal hypothalamic regulation of body metabolism and bone density is galanin dependent

Supplement: 2019-04 Idelevich et al JCI (from our google drive)

‌3/18/19 ‌Dr. Xu Xiao
Tontonoz Lab
‌Cell Metabolism

Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD+ Recycling

Supplement: 2019-03 Kim et al Cell Metabolism.pdf (from google drive)

‌2/25/19 ‌‌Dr. Huan Wang
Reue Lab
Cell

Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation

Supplement: 2019-02 Brandt et al Cell.pdf (from google drive)

‌1/28/19 ‌Dr. Prashant Rajbhandari
Tontonoz Lab
Nature Metabolism

The long noncoding RNA CHROME regulates cholesterol homeostasis in primates

Supplement: Hennessy et al Nature Met 2019.pdf (from google drive)

11/16/18 Dr. Bethan Clifford
Tarling/Vallim Lab
Cell Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes
10/19/18 Dr. Christina Priest
Tontonoz Lab
Cell Metabolism Acute and Repeated Treatment with 5-PAHSA or 9-PAHSA Isomers Does Not Improve Glucose Control in Mice
9/21/18 Dr. Michael Shum
Liesa Lab
Cell Metabolism The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase
8/17/18 Dr. Zhi Zhang
Correa Lab
Cell Reports A Neural Circuit Underlying the Generation of Hot Flushes
7/20/18 Alex Salisbury
Sallam Lab
Cell  The Inner Nuclear Membrane Is a Metabolically Active Territory that Generates Nuclear Lipid Droplets
6/15/18 Dr. Karthickeyan Krishnan
Lusis Lab
Nature Medicine The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis
5/18/18

Joan Cheng              Dr. Jenny Link
Tarling/Vallim Lab

Cell Metabolism Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism
4/20/18

‌Dr. Allison Chi
Bensinger Lab

Nature

Innate and Adaptive Lymphocytes Sequentially Shape the Gut Microbiota and Lipid Metabolism Link

3/16/18 ‌Dr. Alessandra Ferrari
Tontonoz Lab
Cell

Metabolic Induction of Trained Immunity through the Mevalonate Pathway

‌2/16/18

‌Karen Ong
Reue Lab

Cell Metabolism

System-wide Benefits of Intermeal Fasting by Autophagy

‌1/19/18 ‌Lara Bideyan
Tontonoz Lab
Cell

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis

‌11/17/17

‌Elinor Lee
Tarling/Vallim Lab

Cell Metabolism

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota

‌10/20/17

Dr. Zhengyi Zhang
Sallam Lab

Cell Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity
‌9/8/17 ‌Dr. Karthickeyan Krishnan
Lusis Lab
Cell Metabolism Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis
8/18/17‌ Kevin Qian
Tontonoz Lab
Cell Metabolism Long-Term Cold Adaptation Does Not Require FGF21 or UCP1
‌7/14/17

Dr. Jenny Link
Tarling/Vallim Lab

Nature Medicine Cold-Induced Conversion of Cholesterol to Bile Acids in Mice Shapes the Gut Microbiome and Promotes Adaptive Thermogenesis
‌6/23/17

Alex Salisbury
Tontonoz Lab

Nature Methods Unexpected Mutations After CRISPR–Cas9 Editing in Vivo
5/19/17‌

Dr. Stephen D. Lee
Tontonoz Lab

Nature Medicine ‌Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis
4/21/2017 ‌Dr. Wayne Hsieh
Bensinger Lab
PLoS Pathogens DENV up-regulates the HMG-CoA reductase activity through the impairment of AMPK phosphorylation: A potential antiviral target
‌3/17/17 Dr. Jie Gao
Tontonoz Lab
Nature Neurotoxic Reactive Astrocytes are Induced by Activated Microglia
2/17/17

Dr. Laurent Vergnes
Reue Lab

‌Nature Persistent microbiome alterations modulate the rate of post-dieting weight regain
1/20/17‌ ‌Dr. Marcus Tol
Tontonoz Lab
Cell ‌Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism
11/18/16‌ ‌Dr. Bo Wang
Tontonoz Lab
Nature Fatty Acid synthesis configures the plasma membrane for inflammation in diabetes‌
‌10/21/16

Dr. Bethan Clifford
Tarling/Vallim Lab

J. Clin. Invest. ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors‌
‌9/16/16 Jose L. Orozco
Tontonoz Lab
J. Biol. Chem Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation
‌8/19/16 ‌Dr. Li Zhang
Tontonoz Lab
Nature TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis
6/17/16

Albert Sek
Reue Lab

Cell The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia
‌5/20/16

‌Dr. Xin Rong
Tontonoz Lab

Cell Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts
‌4/15/16

‌Dylan Zhou and Joe Argus
Bensinger Lab

Dev. Cell Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells
‌3/18/16

‌Dr. Liz Tarling
Tarling/Vallim Lab

Science Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease‌
2/19/16‌

‌Dr. Prashant Rajbhandari
Tontonoz Lab

Nature Depletion of fat-resident Treg cells prevents age-associated insulin resistance
‌1/15/16

Dr. Jihane Benhammou
Beaven Lab

NEJM ‌FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
‌11/20/15

J‌aspreet Sandhu
Tontonoz Lab

Cell ‌Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis
10/16/15

Dr. Stephen D. Lee
Tontonoz Lab

Nature The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1