Publications

  1. Umar S, Hessel M, Steendijk P, Bax W, Schutte C, Schalij M, van der Wall E, Atsma D, van der Laarse  A  (2007). Activation  of signaling  molecules and  matrix  metalloproteinases in  right ventricular myocardium of rats with  pulmonary  hypertension.  Pathology-Research  and Practice,  203:863-872.   PMID:  17913382.  
  1. Umar S, Bax J, Klok M, van Bommel R, Hessel M, den Adel B, Bleeker G, Henneman M, Atsma D, van der Wall E, Schalij M, van der Laarse A (2008). Myocardial collagen metabolism in  failing  hearts  before  and  during  cardiac  resynchronisation  therapy.  European  Journal  of Heart  Failure,10:878-883.   PMID: 18768351. doi: 10.1016/j.ejheart.2008.06.019
  1. Umar S, de Visser Y, Steendijk P, Schutte C, Laghmani El H, Wagenaar G, Bax W, Mantikou E, Pijnappels D, Atsma D, Schalij M, Van der Wall E, van der Laarse A (2009). Allogenic stem cell therapy improves right ventricular function by improving lung pathology in rats with pulmonary hypertension. Am J Physiol Heart Circ Physiol., 297:H1606-H1616. PMID: 19783775. 
  1. Umar S, van der Valk E, Schalij M, van der Wall E, Atsma D, van der Laarse A (2009). Integrin stimulation-induced hypertrophy in neonatal rat cardiomyocytes is NO-dependent. Molecular and Cellular Biochemistry, 320:75-84. PMID: 18690413. 
  1. Umar S, Steendijk P, Ypey DL, Atsma DE, Van der Wall EE, Schalij MJ, van der Laarse A (2010). Novel approaches to treat pulmonary arterial hypertension. Journal of Biomedicine and Biotechnology,  2010:702836. PMID:  20339474. 
  2. Umar  S,  van  der  Laarse  A  (2010).  Nitric  oxide  and  nitric  oxide  synthase  isoforms  in  the normal, hypertrophic and failing heart. Molecular and Cellular Biochemistry, 333:191-201. PMID: 19618122. 
  3. Swildens J,  de Vries  T, Zhongyan Li,  Umar S, Atsma DE, Schalij MJ, van der  Laarse A (2010). Integrin stimulation favors uptake of macromolecules by cardiomyocytes in vitro. Cell Physiol Biochem 2010;26:999-1010. PMID:  21220931.  
  4. Rahman S, Li J, Bopassa J, Umar S, Iorga A, Partownavid P, Sadoshima J, Eghbali M (2011). Phosphorylation       of       GSK-3b Mediates       Intralipid-induced       Cardioprotection      against Ischemia/Reperfusion Injury. Anesthesiology. 2011 Aug;115(2):242-53. PMID: 21691195. 
  5. Umar S, Iorga A, Li J, Matori H, Maltese F, van der Laarse A, Eghbali M (2011). Estrogen rescues pre-existing severe pulmonary arterial hypertension in rats. American Journal of Respiratory and Critical Care Medicine 2011 Sep 15;184(6):715-23. PMID: 21700911. 
  6. Umar S, Li J, Maltese F, Partownavid P, van der Laarse A, Eghbali M (2011). Intralipid prevents and rescues fata pulmonary arterial hypertension and right ventricular failure in rats. Hypertension. 2011 Sep;58(3):512-8. PMID: 21747043. 
  7. Partownavid P, Umar S, Li J, Rahman S, Eghbali M (2011). Fatty-acid oxidation and calcium homeostasis are involved in the rescue of bupivacaine-induced cardiotoxicity by lipid emulsion in rats. Crit Care Med. 2012 Aug;40(8):2431-7. PMID: 22647409.
  8. Umar S, Lee JH, de Lange E, Iorga A, Partow-Navid R, Bapat A, van der Laarse A, Saggar R, Saggar R, Ypey DL,  Karagueuzian  HS,  Eghbali  M  (2012).  Spontaneous  Ventricular Fibrillation in Right Ventricular Failure Secondary to Chronic Pulmonary Hypertension. Circulation-Arrhythmia and Electrophysiology. 2012 Feb 1;5(1):181-90. PMID: 22199010.   
  9. Umar S, Rabinovitch M, Eghbali M (2012). Estrogen Paradox in Pulmonary Hypertension: Current Controversies and Future Perspectives. Invited Pulmonary  Perspective  Review. American Journal of Respiratory  and  Critical  Care  Medicine.  2012  Jul  15;186(2):125-31. Epub 2012 May 3. Review. PMID: 22561960
  10. Nadadur RD, Umar S, Wong G, Eghbali M, Iorga A, Matori H, Partow-Navid R, Eghbali M (2012). Reverse right ventricular structural and extracellular matrix remodeling by estrogen in severe pulmonary hypertension. J Appl Physiol. 2012 Jul;113(1):149-58. Epub 2012 May 24. PMID: 22628376 
  11. Matori H, Umar S, Nadadur RD, Sharma S, Partow-Navid R, Afkhami M, Amjedi M, Eghbali M (2012). Genistein, a soy phytoestrogen, reverses severe pulmonary hypertension and prevents right heart failure in rats. Hypertension. 2012 Aug;60(2):425-30. Epub 2012 Jul 2. PMID: 22753213  
  12. Li J, Umar S, Amjedi M, Iorga A, Sharma S, Nadadur RD, Regitz-Zagrosek V, Eghbali M (2012). New frontiers in heart hypertrophy during pregnancy. Am J Cardiovasc Dis. 2012;2(3):192-207. Epub 2012 Jul 25. PMID: 22937489  
  13. Li J, Umar S, Iorga A, Youn JY, Wang Y, Regitz-Zagrosek V, Cai H, Eghbali M (2012). Cardiac vulnerability to ischemia/reperfusion injury drastically increases in late pregnancy. Basic Res Cardiol. 2012 Jul;107(4):271. PMID: 22648276 
  14. Li J, Iorga A, Sharma S, Youn JY, Partow-Navid R, Umar S, Cai H, Rahman S, Eghbali M (2012). Intralipid, a clinically safe compound, protects the heart against ischemia-reperfusion injury more efficiently than cyclosporine-A. Anesthesiology. 2012 Oct;117(4):836-46. PMID: 22814384
  15. Umar S, Nadadur R, Iorga A, Amjedi M, Matori H, Eghbali M (2012). Cardiac structural and hemodynamic changes associated with physiological heart hypertrophy of pregnancy are reversed postpartum. J Appl Physiol. 2012 Oct 15;113(8):1253-9. Epub 2012 Aug 23. PMID: 22923507.
  16. Ypey DL, van Meerwijk WP, Umar S, Pijnappels DA, Schalij MJ, van der Laarse A (2013). Depolarization-induced automaticity in rat ventricular cardiomyocytes is based on the gating properties of L-type calcium and slow Kv channels. Eur Biophys J. 2013 Apr;42(4):241-55. Epub 2012 Oct 23. PMID: 23089919.  
  17. Sharma S, Umar S, Potus F, Iorga A, Wong G, Meriwether D, Breuils-Bonnet S, Mai D, Navab K, Ross D, Navab M, Provencher S, Fogelman AM, Bonnet S, Reddy ST, Eghbali M (2014). ApoA-I Mimetic Peptide 4F Rescues Pulmonary Hypertension by Inducing MicroRNA- 193-3p. Circulation. 2014 Aug 26;130(9):776-85. Epub 2014 Jun 24.
  18. Li J, Chen X, Mcclusky R, Ruiz-Sundstrom M, Itoh Y, Umar S, Arnold AP, Eghbali M (2014). The number of X chromosomes influences protection from cardiac ischaemia/reperfusion injury in mice: one X is better than two. Cardiovasc Res (2014). First published online: March 19, 2014.
  19. van der  Laarse  A,  Cobbaert  CM,  Umar  S (2015).  Stem and  progenitor  cell  therapy  for pulmonary arterial hypertension: effects on the right ventricle (2013 Grover Conference Series). Pulmonary Circulation. Vol. 5, No. 1, March 2015. 
  20. Partownavid P, Sharma S, Li J, Umar S, Rahman S,  Eghbali  M  (2015).  Involvement of Opioid Receptors in the Lipid Rescue of  Bupivacaine-Induced  Cardiotoxicity.  Anesth  Analg. 2015 Aug;121(2):340-7. PMID: 25993392
  21. Sharma S, Umar S, Centala A, Eghbali M  (2015).  Role of  miR206  in  genistein-induced rescue of pulmonary hypertension in monocrotaline model. J Appl Physiol (1985). 2015 Dec 15;119(12):1374-82. Epub 2015 Oct 15. PMID: 26472874
  22. Iorga A, Li J, Sharma S, Umar S, Bopassa JC, Nadadur RD, Centala A, Ren S, Saito T, Toro L, Wang Y, Stefani E, Eghbali M (2016). Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy. J Am Heart Assoc. 2016 Jan 22;5(1). pii: e002482. PMID: 26802104
  23. Anwar A, Ruffenach G, Mahajan A, Eghbali M, Umar S (2016). Novel biomarkers for pulmonary arterial hypertension (2016). Respir Res. 2016 Jul 20;17(1):88. Review. PubMed PMID: 27439993; PubMed Central PMCID: PMC4955255.
  24. Sharma S, Ruffenach G, Umar S, Motayagheni N, Reddy ST, Eghbali M (2016). Role of oxidized lipids in pulmonary arterial hypertension (2016). Pulm Circ. 2016 Sep;6(3):261-73. Review. PubMed PMID: 27683603; PubMed Central PMCID:  PMC5019079.
  25. Li J, Ruffenach G, Kararigas G, Cunningham CM, Motayagheni N, Barakai N, Umar S, Regitz-Zagrosek V, Eghbali M (2017). Intralipid protects the heart in late pregnancy against ischemia/reperfusion injury via Caveolin2/STAT3/GSK-3β pathway. J Mol Cell Cardiol. 2017 Jan;102:108-116. PubMed  PMID: 27847332.
  26. Umar  S,  Partow-Navid  R,  Ruffenach  G,  Iorga  A,  Moazeni  S,  Eghbali  M  (2017).  Severe Pulmonary  Hypertension  in  Aging  Female  Apolipoprotein  E  Deficient  Mice  is  Rescued  by Estrogen Replacement Therapy. Biol Sex Differ. 2017 Mar 20;8:9. eCollection 2017. PMID: 28344760  
  27. Umar S, Cunningham CM, Itoh Y, Moazeni S, Vaillancourt M, Sarji S, Centala A, Arnold AP, Eghbali M (2017). The Y Chromosome Plays a Protective Role in Experimental Hypoxic Pulmonary Hypertension. Am J Respir Crit Care Med. 2017 Sep 21. [Epub ahead of print] PubMed PMID: 28934553.
  28. Iorga A, Cunningham CM, Moazeni S, Ruffenach G, Umar S, Eghbali M (2017). The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy. Biol Sex Differ. 2017 Oct 24;8(1):33. Review. PubMed PMID: 29065927; PubMed Central PMCID: PMC5655818.
  29. Vaillancourt M, Chia P, Sarji S, Nguyen J, Hoftman N, Ruffenach G, Eghbali M, Mahajan A and Umar S (2017). Autonomic nervous system involvement in pulmonary arterial hypertension. Respiratory Research201718:201.
  30. Hsu JJ, Lu J, Umar S, Lee JT, Kulkarni RP, Ding Y, Chang CC, Hsiai TK, Hokugo A, Gkouveris I, Tetradis S, Nishimura I, Demer LL, Tintut Y (2018). Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice. American journal of physiology. Heart and circulatory physiology. 2018; 314(6):H1203-H1213. PubMed [journal]PMID: 29451816 PMCID: PMC6032086.
  31. Umar S, Li J, Hannabass K, Vaillancourt M, Cunningham CM, Moazeni S, Mahajan A, Eghbali M (2018). Free Fatty Acid Receptor G-protein-coupled Receptor 40 Mediates Lipid Emulsion-induced Cardioprotection. Anesthesiology. 2018 July; 129(1):154-162. PubMed [journal]PMID: 29620570.
  32. Iorga A, Umar S, Ruffenach G, Aryan L, Li J, Sharma S, Motayagheni N, Nadadur RD, Bopassa JC, Eghbali M (2018). Estrogen rescues heart failure through estrogen receptor Beta activation. Biol Sex Differ. 2018 Oct 30;9(1):48. PMID: 30376877
  33. Umar S, Eghbali M (2019). In Reply. Anesthesiology. Anesthesiology. 2019 Mar;130(3):519-521. PMID: 30762648
  34. Le T, Makar C, Morway P, Hoftman N, Umar S (2019). Pulmonary Artery Denervation: A Novel Treatment Modality for Pulmonary Hypertension. Invited Editorial. Journal of Thoracic Disease. J Thorac Dis. 2019 Apr;11(4):1094-1096. PMID: 31179049 PMCID: PMC6531721.
  35. Ruffenach G, Umar S, Vaillancourt M, Hong J, Cao N; Sarji S, Moazeni S, Cunningham C, Ardehali A, Reddy ST, Saggar R, Fishbein G, Eghbali M (2019). Histological hallmarks and role of Slug/PIP axis in Pulmonary Hypertension secondary to Pulmonary Fibrosis. EMBO Mol Med. 2019 Aug 29:e10061. [Epub ahead of print] PMID: 31468711.
  36. Vaillancourt M, Chia P, Medzikovic L, Cao N, Ruffenach G, Younessi D, Umar S (2019). Experimental pulmonary hypertension is associated with neuroinflammation in the spinal cord. Front Physiol. 2019 Sep 20;10:1186. eCollection 2019. PMID: 31616310
  37. Mikhael M, Makar C, Wissa A, Le T, Eghbali M, Umar S (2019). Oxidative Stress and Its Implications in the Right Ventricular Remodeling Secondary to Pulmonary Hypertension. Front Physiol. 2019;10:1233.  eCollection 2019. Review. PubMed PMID: 31607955; PubMed Central PMCID: PMC6769067.
  38. Umar S, Ruffenach G, Moazeni S, Vaillancourt M, Hong J, Cunningham C, Cao N, Navab S, Sarji S, Li M, Lee L, Fishbein G, Ardehali A, Navab M, Reddy ST, Eghbali M (2020). Involvement of Low-Density Lipoprotein Receptor in the Pathogenesis of Pulmonary Hypertension. J Am Heart Assoc. 2020 Jan 21;9(2):e012063. Epub 2020 Jan 9.
  39. Aryan L, Medzikovic L, Umar S, Eghbali M (2020). Pregnancy-associated cardiac dysfunction and the regulatory role of microRNAs. Biol Sex Differ. 2020 Apr 6;11(1):14. Review. PubMed PMID: 32252821; PubMed Central PMCID: PMC7137306.
  40. Aryan L, Younessi D, Zargari M, Banerjee S, Agopian J, Rahman S, Borna R, Ruffenach G, Umar S, Eghbali M (2020). The Role of Estrogen Receptors in Cardiovascular Disease. Int J Mol Sci. 2020 Jun 17;21(12). Review. PubMed PMID: 32560398; PubMed Central PMCID: PMC7352426.
  41. Park JF, Banerjee S, Umar S (2020). In the eye of the storm: the right ventricle in COVID-19. Pulm Circ. 2020 Jul-Sep;10(3):2045894020936660. eCollection 2020 Jul-Sep. Review. PubMed PMID: 32655856; PubMed Central PMCID: PMC7333504.
  42. Ruffenach G, O'Connor E, Vaillancourt M, Hong J, Cao N, Sarji S, Moazeni S, Papesh J, Grijalva V, Cunningham CM, Shu L, Chattopadhyay A, Tiwari S, Mercier O, Perros F, Umar S, Yang X, Gomes AV, Fogelman AM, Reddy ST, Eghbali M (2020). Oral 15-Hydroxyeicosatetraenoic Acid Induces Pulmonary Hypertension in Mice by Triggering T Cell-Dependent Endothelial Cell Apoptosis. Hypertension. 2020 Sep;76(3):985-996. Epub 2020 Jul 27. PubMed PMID: 32713273.
  43. Seger CD, Wang L, Dong X, Tebon P, Kwon S, Liew EC, Marijic J, Umar S, Hoftman NN (2020). A Novel Negative Pressure Isolation Device for Aerosol Transmissible COVID-19. Anesth Analg. 2020 Sep;131(3):664-668. PubMed PMID: 32541251; PubMed Central PMCID: PMC7302060.
  44. Bae DJ, Tehrani DM, Rabadia SV, Frost M, Parikh RV, Calfon-Press M, Aksoy O, Umar S, Ardehali R, Rabbani A, Bokhoor P, Nsair A, Currier J, Tobis J, Fonarow GC, Dave R, Rafique AM (2020). Angiotensin Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker Use Among Outpatients Diagnosed With COVID-19. Am J Cardiol. 2020 Oct 1;132:150-157. Epub 2020 Jul 12. PubMed PMID: 32819683; PubMed Central PMCID: PMC7354276.
  45. Anwar A, Seger C, Tollefson A, Diachun CAB, Tanaka P, Umar S (2020). Medical education in the COVID-19 era: Impact on anesthesiology trainees. J Clin Anesth. 2020 Nov;66:109949. Epub 2020 Jun 1. PubMed PMID: 32504968; PubMed Central PMCID: PMC7262539.
  46. Razee A, Umar S (2021). Editorial Commentary: Pulmonary Artery Denervation for Pulmonary Hypertension: Recent Updates and Future Perspectives. Trends Cardiovasc Med. 2021 May;31(4):261-263. PubMed PMID: 32434044.
  47. Hong J, Arneson D, Umar S, Ruffenach G, Cunningham CM, Ahn IS, Diamante G, Bhetraratana M, Park JF, Said E, Huynh C, Le T, Medzikovic L, Humbert M, Soubrier F, Montani D, Girerd B, Trégouët DA, Channick R, Saggar R, Eghbali M, Yang X (2021). Single-Cell Study of Two Rat Models of Pulmonary Arterial Hypertension Reveals Connections to Human Pathobiology and Drug Repositioning. Am J Respir Crit Care Med. 2021 Apr 15;203(8):1006-1022. PubMed PMID: 33021809; PubMed Central PMCID: PMC8048757.
  48. Park JF, Clark VR, Banerjee S, Hong J, Razee A, Williams T, Fishbein G, Saddic L, Umar S (2021). Transcriptomic Analysis of Right Ventricular Remodeling in Two Rat models of Pulmonary Hypertension: Identification and Validation of EMT in Human Right Ventricular Failure. Circ Heart Fail. 2021 Feb;14(2):e007058. Epub 2021 Feb 5. PMID: 33541093 PMCID: PMC7887079.
  49. Potus F, Frump AL, Umar S, R Vanderpool R, Al Ghouleh I, Lai YC (2021). Recent advancements in pulmonary arterial hypertension and right heart failure research: overview of selected abstracts from ATS2020 and emerging COVID-19 research. Pulm Circ. 2021 Jul-Sep;11(3): 20458940211037274. eCollection 2021 Jul-Sep. Review. PubMed PMID: 34434543; PubMed Central PMCID: PMC8381443.
  50. Cunningham CM, Li M, Ruffenach G, Doshi M, Aryan L, Hong J, Park J, Hrncir H, Medzikovic L, Umar S, Arnold AP, Eghbali M (2022). Y-Chromosome Gene, Uty, Protects Against Pulmonary Hypertension by Reducing Proinflammatory Chemokines. Am J Respir Crit Care Med. 2022 May 3. Epub ahead of print. PMID: 35504005.
  51. Borna R, Rahimian R, Natalie Koons BS, Grogan TR, Umar S, Turner J (2022). Needlestick injuries among anesthesia providers from a large US academic center: A 10-year retrospective analysis. J Clin Anesth. 2022 May 26;80:110885. Epub ahead of print. PMID: 35644082.
  52. Sherman C, Koons N, Zargari M, Cha C, Hirsch J, Hong R, Eghbali M, Umar S (2022). Intralipid fails to rescue bupivacaine-induced cardiotoxicity in late-pregnant rats. Front Med (Lausanne). 2022;9:899036. eCollection 2022. PubMed PMID: 36035396; PubMed Central PMCID: PMC9411664.
  53. Banerjee S, Hong J, Umar S (2022). Comparative analysis of right ventricular metabolic reprogramming in pre-clinical rat models of severe pulmonary hypertension-induced rightventricular failure. Front. Cardiovasc. Med. 9:935423. 
  54. Hong J, Wong B, Huynh C, Tang B, Ruffenach G, Li M, Umar S, Yang X, Eghbali M (2022). Tm4sf1-marked Endothelial Subpopulation Is Dysregulated in Pulmonary Arterial Hypertension. Am J Respir Cell Mol Biol. 2022 Oct 17. Epub ahead of print. PMID: 36252184.
  55. Zhang V, Ganz T, Nemeth E, Umar S*, Kim A (2022). Bmpr2 mutant mice are an inadequate model for studying iron deficiency in pulmonary hypertension. Pulm Circ. 2022 Oct;12(4):e12151. eCollection 2022 Oct. PubMed PMID: 36568690; PubMed Central PMCID: PMC9768458. (Impact Factor: 2.886) (*Co-senior and corresponding author).
  56. Park J, Banerjee S, Hong J, Umar S (2022). Response by Park et al to Letter Regarding Article, "Transcriptomic Analysis of Right Ventricular Remodeling in Two Rat Models of Pulmonary Hypertension: Identification and Validation of Epithelial-to-Mesenchymal Transition in Human Right Ventricular Failure". Circ Heart Fail. 2022 Jul;15(7):e008632. doi: 10.1161/CIRCHEARTFAILURE.122.008632. Epub 2022 Jun 29. PMID: 35766030; PMCID: PMC9348824.
  57. Hoftman N, Umar S (2023). Ventilation and Complications after Lung Resection: Comment. Anesthesiology. 2023 Jun 1;138(6):664-665. doi: 10.1097/ALN.0000000000004512. PMID: 36787157.
  58. Park JF, Liang J, Umar S (2023). Electrical Remodeling in Right Ventricular Failure Due to Pulmonary Hypertension: Unraveling Novel Therapeutic Targets. Int J Mol Sci. 2023 Feb 27;24(5):4633. doi: 10.3390/ijms24054633. PMID: 36902065; PMCID: PMC10003421.
  59. Banerjee S, Zargari M, Russino H, Medzikovic L, Mikhael M, Koons N, Grogan T, Rahman S, Eghbali M, Umar S (2023). Intralipid® improves left ventricular function in rats with lipopolysaccharide-induced endotoxaemia by a Src-STAT3-mediated mechanism. Br J Anaesth. 2022 Nov 30:S0007-0912(22)00590-6. Epub ahead of print. PMID: 36462942.
  60. Razee A, Banerjee S, Hong J, Magaki S, Fishbein G, Ajijola OA, Umar S (2023). Thoracic Spinal Cord Neuroinflammation as a Novel Therapeutic Target in Pulmonary Hypertension. Hypertension. 2023 Jun;80(6):1297-1310. doi: 10.1161/HYPERTENSIONAHA.122.20782. Epub 2023 Apr 24. PMID: 37092338; PMCID: PMC10192067.

  61. Hon A, Hsu JJ, Zambrano A, Xia Y, Lu M, Echeverri D, Kalanski S, Umar S, Demer LL, Tintut Y (2023). Effects of activity levels on aortic calcification in hyperlipidemic mice as measured by microPETmicroCT. Atherosclerosis. 2023 Sep;380:117198. doi: 10.1016/j.atherosclerosis.2023.117198. Epub 2023 Aug 2. PMID: 37579593.