Research: Current Projects
CryoEM Methods Development
Unleash the power of Cryo-Electron Microscopy (CryoEM), one of the most transformative technologies in the field of structural biology! Our lab is not just utilizing this revolutionary tool, but we're pioneering new methodologies to expand its reach and applicability. Our research pushes the boundaries of CryoEM, aiming to enhance resolution, improve sample preparation, and streamline data analysis. We're excited to be at the forefront of these developments, enabling a deeper understanding of the molecular machinery of life and providing a robust platform for future breakthroughs.
Ion-beam Milling Biological Material
Automation is transforming every facet of our lives, and scientific research is no exception. At the heart of our laboratory is a strong emphasis on automating and optimizing processes. In particular, we focus on Ion-Beam milling - a technique used to prepare ultrathin, high-quality samples for CryoEM. By enhancing the precision and reproducibility of this process, we're improving the quality of the data we can collect, paving the way for insights of unprecedented detail and accuracy. It's not just about doing things faster, it's about doing things smarter, harnessing technology to reveal the subtle secrets of biological structures.
Rapid Chemical Structure Determination
The ability to quickly determine the structure of chemical compounds is of paramount importance in the world of drug discovery and biological research. Our lab is driving advances in this crucial area, developing and employing techniques to rapidly deduce the three-dimensional arrangement of atoms within a molecule. Our ultimate goal? To drastically reduce the time between compound discovery and functional understanding, accelerating the pace of therapeutic innovation and biological discovery. Our breakthroughs could mean the difference between life and death for patients waiting for new drug therapies.
Membrane Protein Structure and Function
The cellular membrane is like a city's bustling harbor, a critical hub of transport and communication. At its heart lie membrane proteins, gatekeepers and channels that play a crucial role in maintaining the cell's delicate balance. Our research delves into the intricate world of these proteins, seeking to unravel their complex structures and vital functions. By uncovering how these biological marvels operate and interact with their environment, we're contributing to a more profound understanding of cellular processes, aiding in the development of better-targeted drugs and therapies.