CAI Lab

Publications (total citation: 20,027, single most cited 5,611 by Google Scholar, 12-03-2024)

Peer-Reviewed Publications

  1. Zong NC, Zhang Y, Huang Y, Cai H. Addressing healthy aging: Time to stop a Tsunami of rising Alzheimer's disease. Aging and Disease. 2024. In press. 
     
  2. Murugesan P*, Zhang Y*, Huang Y*, Zong NC*, Youn JY, Chen W, Wang C, Loscalzo J, Cai H. Reversal of pulmonary hypertension in a human-like model: therapeutic targeting of endothelial DHFR. Circ. Res. 2024 Feb 16;134(4):351-370. *The authors contribute equally to this work.
    [Abstract & Full Text]
     
  3. Murugesan P, Zhang Y, Youn JY, Cai H. Novel and superior treatment of pulmonary hypertension with Netrin-1-derived, modified and improved small peptides. Redox Biol. In revision. 
     
  4. Zhou B*, Zong NC*, Zhang Y, Huang Y, Youn JY, Cai H. Clinical characteristics of a COVID-19 cohort treated at UCLA Ronald Reagan Medical Center during the breaking phase of the pandemic: A retrospective study. Redox Biol. 2024 Jul 2:75:103178. *The authors contribute equally to this work.
    [Abstract & Full Text]
     
  5. Zong NC, Zhang Y, Cai H. Keep gimmicks of toy e-Cigarettes away and juveniles on track towards the tobacco endgame. Chest. 2024. Dec:166(6):P1293-1295. 
     
  6. Fischer M*, Howard-Quijano K*, Zong NC*, Youn JY*, Liu NM, Scovotti J, Grogan T, Mahajan A, Cai H. Perioperative changes in plasma nitrite and IL-6 levels predict postoperative atrial fibrillation (POAF) and acute kidney injury (AKI) after cardiac surgery. Antioxidants. 2024, Aug 9;13(8):971. doi: 10.3390/antiox13080971. *The authors contribute equally to this work.
    [Abstract & Full Text]
     
  7. Zheng Q, Cabrera JT, Tsuji-Hosokawa A, Ramirez F, Cai H, Yuan J, Wang J, Makino A. Enhanced lung endothelial glycolysis is implicated in the development of severe pulmonary hypertension in type 2 diabetes. Am J Physiol Lung Cell Mol Physiol. 2024. In press. 
     
  8. Kempf CL, Song JH, Sammani S, Bermudez T, Hernon VR, Tang L, Cai H, Camp SM, Johnson CA, Basiouny MS, Bloomquist LA, Rioux JS, White C, Veress LA, Garcia JGN.  TLR4 ligation by eNAMPT, a novel DAMP, is essential to sulfur mustard-induced inflammatory lung injury and fibrosis.  European Journal of Respiratory Medicine, 2024; 5: 389- 397. 
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  9. Youn JY, Middlekauff HR, Reudiseuli I, Huang K, Cai H. Endothelial damage in young adult e-cigarette users. Redox Biol. 2023 Mar;62:102688. 
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  10. Zhang Y*, Wang X*, Li X*, Lv S*, Wang H, Liu Y, Zhou J, Gong H, Chen XF, Ren SC, Zhang H, Dai Y, Cai H, Yan B, Chen HZ. SIRT2 deficiency amplifies a cytoplasm-mitochondrial signal to aggravates aging-induced vascular remodeling in humans and mice. European Heart Journal. 2023;44,2746-2759. *The authors contribute equally to this work.
    [Abstract & Full Text]
     
  11. Cabrera JT, Si R, Tsuji-Hosokawa A, Cai H, Yuan JXJ, Dillmann WH, Makino A. Restoration of coronary microvascular function by OGA overexpression in a high-fat diet with low-dose streptozotocin-induced type 2 diabetic mice. Diabetes and Vascular Disease Research. 2023 May-June;1-13. 
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  12. Fischer MA, Chapski DJ, Soehalim E, Montoya DJ, Grogan T, Pellegrini M, Cai H, Shemin RJ, Vondriska TM. Longitudinal profiling in patients undergoing cardiac surgery reveals postoperative changes in DNA methylation. Clin. Epigenetics. 2022 Dec 30;14(1):195. doi: 10.1186/s13148-022-01414-4. 
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  13. Huang K*, Wu Y*, Zhang Y, Youn JY, Cai H. Combination of folic acid with nifedipine is completely effective in attenuating aortic aneurysm formation as a novel oral medication. Redox Biol. 2022 Dec;58:102521. *The authors contribute equally to this work.
    [Abstract & Full Text]
     
  14. Song JH, Mascarenhas JB, Sammani S, Kempf CL, Cai H, Camp SM, Bermudez T, Zhang DD, Natarajan V, Garcia JGN. TLR4 activation induces inflammatory vascular permeability via Dock1 targeting and NOX4 upregulation. Biochim Biophys Acta Mol Basis Dis. 2022 Dec 1;1868(12):166562.
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  15. Zhang Y, Siu KL, Li Q, Howard-Quijano K, Scovotti J, Shemin RJ, Mahajan A, Cai H. Diagnostic and predictive values of circulating tetrahydrobiopterin levels as a novel biomarker in patients with thoracic and abdominal aortic aneurysms. Redox Biol. 2022 Oct;56:102444. 
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  16. Youn JY, Wang J, Li Q, Huang K, Cai H. Robust therapeutic effects on COVID-19 of novel small molecules: Alleviation of SARS-CoV-2 S protein induction of ACE2/TMPRSS2, NOX2/ROS, and MCP-1. Front Cardiovasc Med. 2022;9:957340. 
    [Abstract & Full Text]
     
  17. Sammani S, Bermudez T, Kempf CL, Song JH, Fleming JC, Reyes Hernon V, Hufford M, Tang L, Cai H, Camp SM, Natarajan V, Jacobson JR, Dudek SM, Martin DR, Karmonik C, Sun X, Sun B, Casanova NG, Bime C, Garcia JGN. eNAMPT neutralization preserves lung fluid balance and reduces acute renal injury in porcine sepsis/VILI-induced inflammatory lung injury. Front Physiol. 2022 Jun 22;13:916159. 
    [Abstract & Full Text]
     
  18. Murugesan P, Zhang Y, Youn JY, Cai H. Novel and robust treatment of pulmonary hypertension with netrin-1 and netrin-1-derived small peptides. Redox Biol. 2022 May 26;55:102348. 
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  19. Liu Z*, Zhang Y*, Youn JY, Zhang Y, Makino A, Yuan J, Cai H. Flavored and nicotine-containing E-cigarettes induce impaired angiogenesis and diabetic wound healing via increased endothelial oxidative stress and reduced NO bioavailability. Antioxidants. 2022, 11(5), 904. *The authors contribute equally to this work.
    [Abstract & Full Text]
     
  20. Garcia AN, Casanova NG, Kempf CL, Bermudez T, Valera DG, Song JH, Sun X, Cai H, Moreno-Vinasco L, Gregory T, Oita RC, Hernon VR, Camp SM, Rogers C, Kyubwa EM, Menon N, Axtelle J, Rappaport J, Bime C, Sammani S, Cress AE, Garcia JGN. eNAMPT is a novel damage-associated molecular pattern protein that contributes to the severity of radiation-induced lung fibrosis. Am J Respir Cell Mol Biol. 2022 May;66:497-509. 
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  21. Youn JY*, Zhang Y*, Wu Y, Cannesson M, Cai H. Therapeutic application of estrogen for COVID-19: Attenuation of SARS-CoV-2 spike protein and IL-6 stimulated, ACE2-dependent NOX2 activation, ROS production and MCP-1 upregulation in endothelial cells. Redox Biol. 2021 Aug 17;46:102099. *The authors contribute equally to this work.
    [Abstract & Full Text]

  22. Huang K*, Narumi T*, Zhang Y, Li Q, Murugesan P, Wu Y, Liu NMJ, Cai H. Targeting miR-192-5p, a downstream effector of NOXs, reverses endothelial dihydrofolate reductase deficiency to attenuate abdominal aortic aneurysm formation. Hypertension. 2021 Aug;78:282-293. *The authors contribute equally to this work.
    [Abstract & Full Text]

  23. Guo Z*, Zhang Y*, Liu C*, Youn JY, Cai H. Toll-like receptor 2 (TLR2) knockout abrogates diabetic and obese phenotypes while restoring endothelial function. Diabetes. 2021 Sep;70:1-13. *The authors contribute equally to this work.
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  24. Huang K*, Zhang P*, Zhang Z*, Youn JY*, Wang C, Zhang H, Cai H. Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and viral infections: Efficacies and mechanisms. Pharmacology and Therapeutics. 2021 Sep;225:107843. *The authors contribute equally to this work.
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  25. Huang K*, Wang Y*, Siu KL*, Zhang Y, Cai H. Targeting feed-forward signaling of TGFβ/NOX4/DHFR/eNOS uncoupling/TGFβ axis with anti-TGFβ and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics. Redox Biology. 2021 Jan;38:101757. *The authors contribute equally to this work.
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  26. Cai H. Sex difference and smoking predisposition in patients with COVID-19. Lancet Respiratory Medicine. 2020 April. doi: 10.1016/S2213-2600(20)30117-X. "Most Read Article".
    [Abstract & Full Text] [Most Read Article -1] [Most Read Article -2]

  27. Zhang Y, Murugesan P, Huang K, Cai H. NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets. Nature Reviews Cardiology. 2020 Mar;17(3):170-194. doi: 10.1038/s41569-019-0260-8.
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  28. Jiang J, Huang K, Xu S, Garcia JGN, Wang C, Cai H. Targeting NOX4 alleviates sepsis-induced acute lung injury via attenuation of redox-sensitive activation of CaMKII/ERK1/2/MLCK and endothelial cell barrier dysfunction. Redox Biology. 2020 Sep;36:101638. 
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  29. Cai H, Garcia JGN, Wang C.  More to add to e-cigarette regulations: Unified approaches. Chest. 2020 Apr:157(4)771-773. 
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  30. Li Q, Youn JY, Siu KL, Murugesan P, Zhang Y, Cai H. Knockout of dihydrofolate reductase in mice induces abdominal aortic aneurysm and hypertension via mitochondrial dysfunction. Redox Biology. 2019 Mar 29;24:101185. doi: 10.1016/j.redox.2019.101185.
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  31. Li H*, Li Q*, Zhang Y, Liu W, Gu B, Narumi T, Siu KL, Youn JY, Liu P, Yang X, Cai H. Novel treatment of hypertension by specifically targeting E2F for the restoration of dihydrofolate reductase and eNOS function under oxidative stress. Hypertension. 2019 Jan;73(1):179-189. *The authors contribute equally to this work. “High Impact Paper in Hypertension” collection. "Editor's pick". "Featured by live Twitter session".
    [Abstract & Full Text]

  32. Zhang Y*, Wang L*, Mutlu GM, Cai H. More to Explore: Further Definition of Risk Factors for COPD – Differential Gender Difference, Modest Elevation in PM2.5, and e-Cigarette Use. Front Physiol. 2021 May 5;12:669152. *The authors contribute equally to this work.
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  33. Cheng Y*, Yuan Q*, Vergnes L, Rong X, Youn JY, Li J, Yu Y, Liu W, Cai H, Lin J, Tontonoz P, Hong C, Reue K, Wang CY. KDM4B protects against obesity and metabolic dysfunction. Proc. Natl. Acad. Sci. U. S. A. 2018 115(24):E5566-E5575. *The authors contribute equally to this work.
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  34. Cai H, Wang C. Surviving With Smog and Smoke: Precision Interventions? Chest. "Ahead of the Curve" Collection, 2017 Nov;152(5):925-929. doi: 10.1016/j.chest.2017.06.030.
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  35. Cai H, Wang C. Graphical review: The redox dark side of e-cigarettes; exposure to oxidants and public health concerns. Redox Biology. 2017 Oct;13:402-406. doi: 10.1016/j.redox.2017.05.013.
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  36. Zhang Y, Cai H. Endothelial to mesenchymal transition: When the good one goes bad. Editorial comments on "Endothelial to mesenchymal transition: A novel therapeutic target for cardiovascular diseases". (2017) Trends in Cardiovasc Med.
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  37. Zhang Y, Liu NM, Wang Y, Youn JY, Cai H. Endothelial cell calpain as a critical modulator of angiogenesis. (2017) BBA Mol. Basis of Disease. 1863(6):1326-1335. PMID: 28366876.
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  38. Liu NM*, Siu KLI, Youn JY, Cai H. Attenuation of neointimal formation with netrin-1 and netrin-1 preconditioned endothelial progenitor cells. (2017) J. Mol. Med. 95(3):335-348. *The authors contribute equally to this work.
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  39. Siu KL*, Li Q*, Zhang Y, Guo J, Youn JY, Du J, Cai H. NOX isoforms in the development of abdominal aortic aneurysm. (2017) Redox Biology. 11:118-125. *The authors contribute equally to this work.
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  40. Zhang Y, Li Q, Youn JY, Cai H. PTP1B in calpain-dependent feedback regulation of VEGFR2 in endothelial Cells: implication in VEGF-dependent angiogenesis and diabetic wound healing. (2017) J. Biol. Chem. 292(2):407-416. doi: 10.1074/jbc.M116.766832.
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  41. Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ 2nd, Madhur MS, Harrison DG. Immune activation caused by vascular oxidation promotes fibrosis and hypertension. (2016) J. Clin. Invest. 126(1):50-67. PMCID: PMC4701546.
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  42. Siu KL, Gao L, Cai H. Differential roles of protein complexes NOX1-NOXO1 and NOX2-p47phox in mediating endothelial redox responses to oscillatory and unidirectional laminar shear stress. (2016) J. Biol. Chem. 291(16):8653-62. PMCID: PMC4861435.
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  43. Sun H, Olson K, Chen G, Prosdocimo DA, Zhou M, Wang Z, Zeyaraj D, Youn JY, Ren S, Shah S, Newgard C, Cai H, Ping P, Schulze PC, Lynch C, Jain MK, Wang YB. Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure. (2016) Circulation. 133(21):2038-49. PMCID: PMC4879058.
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  44. Miao XN, Siu KL, Cai H. Nifedipine attenuation of abdominal aortic aneurysm in hypertensive and non-hypertensive mice: Mechanisms and implications. (2015) J. Mol. Cell. Cardiol. 87:152-9. PMCID: PMC4637219.
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  45. Li Q, Youn JY, Li S, Cai H. A central role of tetrahydrobiopterin deficiency in eNOS uncoupling in hypertension, Reply to "Creatine synthesis demands the majority of the bioavailable L-arginine", (2015) J. Hyperten. 33(11):2368-70. PMCID: PMC4819245.
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  46. Youn JY, Zhou J, Cai H. Bone morphogenic protein 4 mediates NOX1-dependent eNOS uncoupling, endothelial dysfunction and COX2 induction in type 2 diabetes mellitus. (2015) Mol. Endocrinology. 29(8):1123-33. PMCID: PMC4518001.
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  47. Li Q, Cai H. Induction of cardioprotection by netrin-1 derived small peptides. Am. J. Physiol. Cell Physiol. 2015 Jul 15;309(2):C100-6. PMID: 25924621.
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  48. Ping P, Gustafasson A, Bers D, Blatter L, Cai H, Jahangir A, Kelly D, Muoio D, O'Rourke B, Rabinovitch P, Trayanova N, Van Eyke J, Weiss JN, Wong R, Longacre LS. Harnessing the power of integrated mitochondrial biology and physiology: A special report on the NHLBI mitochondria in heart disease initiative. Circ Res. 2015 Jul 17;117(3):234-8. PMID: 26185209.
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  49. Li Q, Cai H. ANO1 taking center stage: Blood pressure regulation in SHRs. Editorial comments on "Overexpression of ANO1/TMEM16A, an arterial Ca2+-activated Cl- channel, contributes to spontaneous hypertension". J. Mol. Cell. Cardiol. (2015) March 26;82:216-7. PMID: 25817885.
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  50. Youn JY, Cai H. Fueling up the skeletal muscle to reduce obesity: A TrkB story. Editorial comments on "Activation of muscular TrkB by its small molecule agonist 7,8-dihydroxyflavone sex-dependently regulates energy metabolism in diet-induced obese mice". Chemistry and Biology, (2015) March 19;22(3):311-2 PMID: 25794433.
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  51. Li Q, Youn JY, Cai H. Mechanisms and consequences of eNOS dysfunction in hypertension. J. Hyperten. 2015 Jun;33(6):1128-36. Highlighted Article with Editorial.
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  52. Li Q, Wang P, Ye KQ, Cai H. Central role of SIAH inhibition in DCC-dependent cardioprotection provoked by netrin-1/NO. Proc. Natl. Acad. Sci. U. S. A. (2015) Jan 20;112(3):899-904. PMID: 25561546.
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  53. Siu KL & Cai H. Circulating tetrahydrobiopterin as a novel biomarker for abdominal aortic aneurysm. (2014) Am. J. Physiol. Heart Circ. Physiol. 307(11):H1559-64; online first Sept. 26, 2014. PMID: 25260610.
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  54. Siu KL, Lotz C, Ping PP, Cai H. Netrin-1 abrogates ischemia reperfusion induced mitochondrial dysfunction via attenuation of NOX4 activation and recoupling of NOS. (2014) J. Mol. Cell. Cardiol. 78:174-85; online July 24, 2014. PMID: 25066694.
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  55. Zhang Y, Shimizu H, Siu KL, Mahajan A, Chen JN, and Cai H. NADPH oxidase 4 induces cardiac arrhythmic phenotype in zebrafish. (2014) J. Biol. Chem. 289(33):23200-8; online first June 24, 2014. PMID: 24962575.
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  56. Bouhidel JOB,* Wang P,* Siu KL, Youn JY, Cai H. Netrin-1 improves post-injury cardiac function in vivo via DCC/NO-dependent preservation of mitochondrial function, while attenuating autophagy. (2014) BBA Mol. Basis of Disease 1852(2):277-89; online first June 10, 2014. *The authors contribute equally to this study. PMID: 24928309.
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  57. Siu KL, Miao XN, Cai H. Recoupling of eNOS with folic acid prevents abdominal aortic aneurysm formation in angiotensin II infused apolipoprotein E null mice. (2014) PLOS One 9(2):e88899; online first Feb 2014.
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  58. Youn JY, Siu KL, Lob HE, Itani H, Harrison DG, Cai H. Role of vascular oxidative stress in obesity. (2014) Diabetes 63(7):6344-55; online first Feb 2014. Highlighted Article with Editorial.
    [Abstract & Full Text]

  59. Bouhidel JOB, Wang P, Li Q, Cai H. Pharmacological postconditioning treatment of myocardial infarction with netrin-1. (2014) Frontiers in Bioscience (Landmark Edition) 19:566-570, PMCID: PMC4053198.
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  60. Youn JY, Siu KL, Li Q, Harrison DG, Cai H. Oxidase interaction in cardiovascular disease; in System Biology of Oxidative Stress and Antioxidants. (2013) Editor Laher I, Springer, Chapter 37, 849-76.
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  61. Li Q, Youn JY, Cai H. Role of eNOS uncoupling in hypertension. (2013) Chinese Journal of Hypertension 21(12): 1105-9.

  62. Youn JY, Zhang J, Zhang Y, Chen HZ, Liu DP, Ping PP, Weiss JN, Cai H. Oxidative stress in atrial fibrillation: An emerging role of NADPH oxidase. (2013) J. Mol. Cell. Cardiol. 62:72-9. PMCID: PMC3735724.
    [Abstract & Full Text]

  63. Youn JY, Gao L, Zhang J, Cai H. The p47phox and NOXO1-dependent activation of NOX1 mediates eNOS uncoupling and endothelial dysfunction in diabetes. (2012) Diabetologia. 55(7):2069-79. PMCID: PMC3694990.
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  64. Youn JY, Nguyen A, Chen P, Cai H. Inhibition of XO or NOX attenuates DES-induced NO deficiency without affecting its effect on LNCaP cell apoptosis and invasion. (2012) Clinical Sci. 123(8):509-18. PMCID: PMC3675905.
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  65. Youn JY, Blair J, Wang T, Laude K, Oak JH, McCann LA, Harrison DG, Cai H. Endothelium-specific sepiapterin reductase deficiency in DOCA-salt hypertension. (2012) Am. J. Physiol. Heart Circ. Physiol. 302(11):H2243-9.
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  66. Zhang J, Youn JY, Kim AY, Gao L, Ngo D, Chen P, Ramire RJ, Mahajan A, Cai H. NOX4-dependent hydrogen peroxide production in human atrial fibrillation and HL-1 atrial cells: Relationship to hypertension. (2012) Frontiers in Physiology-Oxidant Physiology 3:104-114.
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  67. Li J, Umar S, Iorga A, Youn JY, Wang Y, Regitz-Zagrosek V, Cai H, Eghbali M. Cardiac vulnerability to ischemia/reperfusion injury drastically increases during late pregnancy. (2012) Basic Res. Cardiol. 107: 271- online first May 21.
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  68. Li J, Iorga A, Youn JY, partow-Navid R, Umar S, Cai H, Eghbali M. Intralipid, a clinically safe compound, protects the heart against ischemia reperfusion injury more efficiently than cyclosporine-A. Anesthesiology (2012) 117(4):836-46.
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  69. Zhang J, Lin A, Powers J, Lotz C, Liem D, Lau E, Wang D, Deng N, Korge P, Zong N, Cai H, Weiss JN, Ping PP. Mitochondrial proteome design: from molecular identity to pathophysiological regulation. (2012) J. Gen. Physiol. 139(6):395-406.
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  70. Siu KL, Gao L, Cai H. Characterization of eNOS uncoupling in vivo and possible cause of H4B insensitivity in vitro: Reply to the Letter to the Editor "Tetrahydrobiopterin and endothelial nitric oxide synthase uncoupling" by Tsikas et al. (2011) Hypertension online first Dec 2011.

  71. Gao L*, Siu KL*, Chalupsky K, Nguyen A, Chen P, Weintraub NL, Galis Z, Cai H. Role of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation: Treatment with folic acid. (2011) Hypertension. 59(1):158-66. *The authors contribute equally to this study. Collected and evaluated by faculty 1000 to be in the top 2% of biology and medicine. PMCID: PMC3668799.
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  72. Zhou S*, Chen HZ*, Wan YZ*, Zhang QJ, Wei YS, Huang S, Liu JJ, Lu YB, Zhang ZQ, Yang RF, Zhang R, Cai H, Liu DP, Liang CC. Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction. Circ Res (2011) Sept 109(6):639-48. *The authors contribute equally to this work.
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  73. Zhang J, Cai H. Netrin-1 prevents ischemia/reperfusion-induced myocardial infarction via a DCC/ERK1/2/eNOSs1177/NO/DCC feed-forward mechanism. J. Mol. Cell. Cardiol. (2010) Jun;48(6):1060-70.
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  74. Oak JH, Youn JY, Cai H. Aminoguanidine inhibits aortic hydrogen peroxide production, VSMC NOX activity and hypercontractility in diabetic mice. Cardiovasc. Diabetology (2009) Dec 30;8:65.
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  75. Shuvaev VV, Christofidou-Solomidou M, Bhora F, Laude K, Cai H, Dikalov S, Arguiri E, Solomides CC, Albelda SM, Harrison D, Muzykantov VR. Targeted detoxification of selected reactive oxygen species in the vascular endothelium. J Pharmacol Exp Ther. (2009) Aug 19;331(2):404-11.
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  76. Gao L, Chalupsky K, Stefani E, Cai H. Mechanistic Insights into Folic Acid-dependent Vascular Protection: Dihydrofolate reductase-mediated Reduction in Oxidant Stress in Endothelial Cells and Angiotensin II-Infused Mice. A Novel HPLC-based Fluorescent Assay for DHFR Activity. J. Mol Cell Cardiol. (2009) Dec;47(6):752-60. Highlighted Article with Editorial.
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  77. Zhuo ML*, Huang Y*, Chen JZ*, Sun LH, Yang RF, Chen HZ, Lv X, Li HL, Wei YS, Liu G, Zhang R, Ma TM, Cai H, Hui RT, Liu DP, Liang CC. Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in mice. Cardiovasc Res. (2009) Nov 1;84(2):292-9. *The authors contribute equally to this work.
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  78. Gao L, Pung YF, Zhang J, Chen P, Wang T, Li M, Meza M, Toro L, Cai H. Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability. Am. J. Physiol. Heart Circ. Physiol. (2009) Jul;297(1):H331-9.
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  79. Lu G, Sun H, She P, Youn JY, Warburton S, Ping P, Vondriska TM, Cai H, Lynch CJ, Wang Y. Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells. J Clin Invest. (2009) June 1; 119(6):1678-1687.
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  80. Youn JY, Wang T, Cai H. An Ezrin/Calpain/PI3K/AMPK/AKT/eNOSs1179 Signaling Cascade Mediating VEGF-dependent Endothelial Nitric Oxide Production. Circ. Res. (2009);104:50-59.
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  81. Zhang QJ*, Wang Z*, Chen HZ*, Zhou S, Zheng W, Liu G, Wei YS, Cai H, Liu DP, Liang CC. Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovasc Res. (2008) Nov 1;80(2):191-9. *The authors contribute equally to this work.
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  82. Cai H, Liu DP, Garcia JG. CaM kinase II-dependent pathophysiological signaling in endothelial cells. Cardiovasc. Res. (2008) Jan;77(1):30-4.
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  83. Cai H, Dikalov S, Griendling KK, Harrison DG. Detection of reactive oxygen species and nitric oxide in vascular cells and tissues: comparison of sensitivity and specificity. Methods Mol Med (2007);139:293-311.
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  84. Li HL*, Zhou ML*, Wang D*, Wang AB, Cai H, Sun LH, Yang Q, Huang Y, Wei YS, Liu DP, Liang CC. Targeted cardiac overexpression of A20 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction. Circulation (2007) Apr 10;115(14):1885-94. *The authors contribute equally to this work.
    [Abstract & Full Text]

  85. Oak JH, Cai H. Attenuation of angiotensin II signaling recouples eNOS and inhibits non-endothelial NOX activity in diabetic mice. Diabetes (2007) Jan 56(1):118-126
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  86. Zhang G, Zhang F, Muh, R, Yi F, Chalupsky K, Cai H, Li PL. Autocrine/paracrine pattern of superoxide production through NAD(P)H oxidase in coronary arterial myocytes. Am. J. Physiol. Heart Circ. Physiol. (2007) Jan; 292(1): H483-95
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  87. Nguyen A, Cai H. Netrin-1 induces angiogenesis via a DCC-dependent ERK1/2-eNOS feed-forward mechanism. Proc Natl Acad Sci U S A. (2006) Track II, Apr 25;103(17):6530-5
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  88. Cai H. Potassium channel as endothelial mechanosensor and modulator of NAD(P)H oxidase: new mechanism for flow-mediated vasoprotection. Editorial comments on "Lung endothelial cell proliferation with decreased shear stress is mediated by reactive oxygen species". (2006) Am J Physiol. Cell Physiol. Jan;290(1):C35-6
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  89. Menshikov M, Plekhanova O, Cai H, Chalupsky K, Parfyonova Y, Bashtrikov P, Tkachuk V, Berk BC. Urokinase stimulates vascular smooth muscle proliferation via redox-sensitive pathways. (2006) Arterioscler. Thromb. Vasc. Biol. 26(4):801-7.
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  90. Cai H. Hydrogen peroxide regulation of endothelial function: Origins, mechanisms and consequences. (2005) Cardiovasc. Res. 68(1):26-36.
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  91. Chalupsky K & Cai H. Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of eNOS. Proc Natl Acad Sci U S A. Track II (2005) 102(25):9056-61.
    [Abstract & Full Text]

  92. Cai H. NAD(P)H oxidase-dependent self-propagation of hydrogen peroxide and vascular disease. (2005) Circ. Res. 96(8): 818-22.
    [Abstract & Full Text]

  93. Nakagawa K, Oak JH, Higuchi O, Tsuzuki T, Oikawa S, Otani H, Mune M, Cai H, Miyazawa T. Ion-trap tandem mass spectrometric analysis of Amadori-glycated phosphatidylethanolamine in human plasma with or without diabetes. (2005) J Lipid Res. Nov;46(11):2514-24.
    [Abstract & Full Text]

  94. McNally JS, Saxena A, Cai H, Dikalov S, Harrison DG. Regulation of xanthine oxidoreductase protein expression by hydrogen peroxide and calcium. Arterioscler Thromb Vasc Biol. (2005) Aug;25(8):1623-8.
    [Abstract & Full Text]

  95. Laude K, Cai H, Fink B, Hoch N, Weber DS, McCann L, Kojda G, Fukai T, Schmidt HH, Dikalov S, Ramasamy S, Gamez G, Griendling KK, Harrison DG. Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice. (2005) Am J Physiol Heart Circ Physiol. 288(1):H7-12.
    [Abstract & Full Text]

  96. Nguyen A, Chen P, Cai H. Role of CaMKII in hydrogen peroxide activation of ERK1/2, p38 MAPK, HSP27 and actin reorganization in endothelial cells. (2004) FEBS Lett. 13;572(1-3):307-13.
    [Abstract & Full Text]

  97. Searles CD, Ide L, Davis ME, Cai H, Weber M. Actin cytoskeleton organization and posttranscriptional regulation of endothelial nitric oxide synthase during cell growth. (2004) Circ. Res. 95(5):488-95.
    [Abstract & Full Text]

  98. Cai H, McNally JS, Weber M, Harrison DG. Oscillatory shear stress regulation of endothelial cellsnitric oxide synthase requires intracellular hydrogen peroxide and CaMKII. (2004) J. Mol. Cell. Cardiol. 37:121-125.
    [Abstract & Full Text]

  99. Harrison DG & Cai H. Endothelial control of vasomotion and nitric oxide production. (2003) Cardiology Clinics 21:289-302.
    [Abstract & Full Text]

  100. Cai H, Griendling KK, Harrison DG. The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular disease. (2003) Trends in Pharmacological Science, 24:471-8.
    [Abstract & Full Text]

  101. Harrison DG, Cai H, Landmesser U, Griendling KK,. Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease. (2003) The Journal of the Renin-Angiotensin-Aldosterone System 4:51-61.
    [Abstract & Full Text]

  102. Davis ME, Cai H, McCann L, Fukai T, Harrison DG. Role of c-Src in regulation of endothelial nitric oxide synthase expression during exercise training. (2003) Am. J. Physiol. Heart Circ. Physiol. 284:H1449-H1453.
    [Abstract & Full Text]

  103. Cai H, Li Z, Davis ME, Kanner W, Harrison DG, Dudley SC. Akt-dependent phosphorylation of serine 1179 and MEK/ERK 1/2 cooperatively mediates the activation of endothelial nitric oxide synthase by hydrogen peroxide. (2003) Molecular Pharmacology 63:325-331.
    [Abstract & Full Text]

  104. Cai H, Li Z, Dikalov S, Holland SM, Hwang J, Jo H, Dudley SC, Harrison DG. NAD(P)H oxidase-derived hydrogen peroxide mediates endothelial nitric oxide production of in response to angiotensin II. (2002) J. Biol. Chem. 277:48311-48317.
    [Abstract & Full Text]

  105. Cai H, Li Z, Goette A, Mera F, Honeycutt C, Feterik K, Dudley SC, Harrison DG, Langberg JJ. Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation. Potential mechanisms for atrial thombosis and stroke. (2002) Circulation 106:2854-2858.
    [Abstract & Full Text]

  106. Landmesser U, Cai H, Dikalov S, McCann L, Hwang J, Jo H, Holland SM, Harrison DG. Role of p47phox in vascular oxidative stress and hypertension caused by angiotensin II. (2002) Hypertension 40:511-515.
    [Abstract & Full Text]

  107. Davis ME, Cai H, Drummond GR, Harrison DG. Shear Stress Regulates Endothelial Nitric Oxide Synthase Expression Through c-Src by Divergent Signaling Pathways. (2001) Circ. Res. 89:1073-1080.
    [Abstract & Full Text]

  108. Cai H, Davis ME, Drummond GR, Harrison DG. Induction of endothelial NO synthase by hydrogen peroxide via a Ca2+/camodulin-dependent protein kinase II/janus kinase 2-dependent pathway. (2001) Arterioscler Thromb Vasc Biol. 21:1571-1576.
    [Abstract & Full Text]

  109. Cai H & Harrison DG. Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress. (2000) Circ. Res. 87:840-844.
    [Abstract & Full Text]

  110. Chan DK, Mellick G, Cai H, Wang XL, Ng PW, Pang CP, Woo J, Kay R. The alpha-synuclein gene and Parkinson disease in a Chinese population. (2000) Arch Neurol. Apr;57(4):501-3.
    [Abstract & Full Text]

  111. Drummond GR, Cai H, Davis ME, Ramasamy S, Harrison DG. Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide. (2000) Circ. Res. 86:347-354.
    [Abstract & Full Text]

  112. Cai H, Wang XL, Wilcken DE. Genetic polymorphism of heparan sulfate proteoglycan (perlecan, HSPG2), lipid profiles and coronary artery disease in the Australian population. (2000) AtherosclerosisJan;148(1):125-9.
    [Abstract & Full Text]

  113. Wang XL, Duarte N, Cai H, Adachi T, Sim AS, Cranney G, Wilcken DE. Relationship between total plasma homocysteine, polymorphisms of homocysteine metabolism related enzymes, risk factors and coronary artery disease in the Australian hospital-based population. (1999) AtherosclerosisSep;146(1):133-40.
    [Abstract & Full Text]

  114. Cai H, Duarte N, Wilcken DE, Wang XL. NADH/NADPH oxidase p22 phox C242T polymorphism and coronary artery disease in the Australian population. (1999) Eur. J. Clin. Invest 29:744-748.
    [Abstract & Full Text]

  115. Cai H, Wilcken DE, Wang XL. The Glu298-->Asp (894G-->T) mutation at exon 7 of the endothelial nitric oxide synthase gene and coronary artery disease. (1999) J. Mol. Med. 77:511-514.
    [Abstract & Full Text]

  116. Wang XL, Duarte N, Cai H, Sim AS, Cranney G, Wilcken DE. Relationship between total plasma homocysteine, polymorphisms of homocysteine metabolism related enzymes, risk factors and coronary artery disease in the Australian hospital-based population. (1999) Atherosclerosis 146:133-140.
    [Abstract & Full Text]

  117. Wang XL, Cai H, Cranney G, Wilcken DE. The frequency of a common mutation of the methionine synthase gene in the Australian population and its relation to smoking and coronary artery disease. (1998) J Cardiovasc Risk Oct-Dec;5(5-6):289-95.
    [Abstract & Full Text]

  118. Cai H, Wang X, Colagiuri S, Wilcken DE. Methionine synthase D919G mutation in type 2 diabetes and its relation to vascular events. (1998) Diabetes Care Oct;21(10):1774-5.
    [Abstract & Full Text]

  119. Cai H, Wang XL, Colagiuri S, Wilcken DE. A common Glu298-->Asp (894G-->T) mutation at exon 7 of the endothelial nitric oxide synthase gene and vascular complications in type 2 diabetes. (1998) Diabetes Care Dec;21(12):2195-2196.
    [Abstract & Full Text]


Invited Book Chapters:

  1. Youn JY, Siu KL, Li Q, Harrison DG, Cai H. Oxidase interaction in cardiovascular disease; in System Biology of Oxidative Stress and Antioxidants. (2013) Editor Laher I, Springer, Chapter 37, 849-76.
    [Abstract & Full Text]

  2. Gao L, Laude K, Cai H. Mitochondrial Pathophysiology, Reactive Oxygen Species, and Cardiovascular Diseases. Veterinary Clinics of North America: Small Animal Practice; (2008) 38(1):137-55, vi.
    [Abstract & Full Text]

  3. Cai H, Dikalov S. Griendling KK, Harrison DG. Detection of reactive oxygen species and nitric oxide in vascular cells: Comparison of sensitivity and specificity. In Vascular Biology Protocols, Editors: N Sreejaya and Ren J, Methods in Molecular Medicine, Humana Press Inc., New York, (2007), pg 293-314
    [Full Text]