The Cai Laboratory

Publications

Peer-Reviewed Publications

  1. Zhang Y, Murugesan P, Huang K, Cai H. NADPH oxiase-dependent oxidase crosstalks in cardiovascular diseases: Targets of novel therapies. Nature Reviews Cardiology. 2019 In press.  

  2. Li Q, Youn JY, Siu KL, Murugesan P, Zhang Y, Cai H. Knockout of dihydrofolate reductase in mice induces abdominal aortic aneurysm and hypertension via mitochondrial dysfunction. Redox Biology. 2019 Mar 29;24:101185. doi: 10.1016/j.redox.2019.101185.
    [Abstract & Full Text]

  3. Li H*, Li Q*, Zhang Y, Liu W, Gu B, Narumi T, Siu KL, Youn JY, Liu P, Yang X, Cai H. Novel treatment of hypertension by specifically targeting E2F for the restoration of dihydrofolate reductase and eNOS function under oxidative stress. Hypertension 2019 Jan;73(1):179-189. *The authors contribute equally to this work. “High Impact Paper in Hypertension” collection.
    [Abstract]

  4. Cheng Y, Yuan Q, Vergnes L, Rong X, Youn JY, Li J, Yu Y, Liu W, Cai H, Lin J, Tontonoz P, Hong C, Reue K, Wang CY. KDM4B protects against obesity and metabolic dysfunction. Proc. Natl. Acad. Sci. U. S. A. 2018 115(24):E5566-E5575
    [Abstract & Full Text]

  5. Cai H, Wang C. Surviving With Smog and Smoke: Precision Interventions? Chest. "Ahead of the Curve" Collection, 2017 Nov;152(5):925-929. doi: 10.1016/j.chest.2017.06.030.
    [Abstract & Full Text]

  6. Cai H, Wang C. Graphical review: The redox dark side of e-cigarettes; exposure to oxidants and public health concerns. Redox Biology. 2017 Oct;13:402-406. doi: 10.1016/j.redox.2017.05.013.
    [Abstract & Full Text]

  7. Zhang YX, Cai H. Endothelial to mesenchymal transition: When the good one goes bad. Editorial comments on "Endothelial to mesenchymal transition: A novel therapeutic target for cardiovascular diseases". (2017) Trends in Cardiovasc Med.
    [Abstract & Full Text]

  8. Zhang YX, Liu NM, Wang YC, Youn JY, Cai H. Endothelial cell calpain as a critical modulator of angiogenesis. (2017) Biochim Biophys Acta. Mol. Basis of Dis. 1863(6):1326-1335. PMID: 28366876
    [Abstract & Full Text]

  9. Liu NM, Siu KL, Youn JY, Cai H. Attenuation of neointimal formation with netrin-1 and netrin-1 preconditioned endothelial progenitor cells. (2017) J. Mol. Med. 95(3):335-348
    [Abstract & Full Text]

  10. Siu KL*, Li Q*, Zhang YX, Guo J, Youn JY, Du J, Cai H. NOX isoforms in the development of abdominal aortic aneurysm. (2017) Redox Biology. 11:118-125. *The authors contribute equally to this work.
    [Abstract & Full Text]

  11. Zhang YX, Li Q, Youn JY, Cai H. PTP1B in calpain-dependent feedback regulation of VEGFR2 in endothelial Cells: implication in VEGF-dependent angiogenesis and diabetic woundhealing. (2017) J. Biol. Chem. 292(2):407-416. doi: 10.1074/jbc.M116.766832.
    [Abstract & Full Text]

  12. Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ 2nd, Madhur MS, Harrison DG. Immune activation caused by vascular oxidation promotes fibrosis and hypertension. (2016) J. Clin. Invest. 126(1):50-67. PMCID: PMC4701546.
    [Abstract & Full Text]

  13. Siu KL, Gao L, Cai H. Differential roles of protein complexes NOX1-NOXO1 and NOX2-p47phox in mediating endothelial redox responses to oscillatory and unidirectional laminar shear stress. (2016) J. Biol. Chem. 291(16):8653-62. PMCID: PMC4861435.
    [Abstract & Full Text]

  14. Sun H, Olson K, Chen G, Prosdocimo DA, Zhou M, Wang Z, Zeyaraj D, Youn JY, Ren S, Shah S, Newgard C, Cai H, Ping P, Schulze PC, Lynch C, Jain MK, Wang YB. Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure. (2016) Circulation. 133(21):2038-49. PMCID: PMC4879058.
    [Abstract & Full Text]

  15. Miao XN, Siu KL, Cai H. Nifedipine attenuation of abdominal aortic aneurysm in hypertensive and non-hypertensive mice: Mechanisms and implications. (2015) J. Mol. Cell. Cardiol. 87:152-9. PMCID: PMC4637219.
    [Abstract & Full Text]

  16. Li Q, Youn JY, Li S, Cai H. A central role of tetrahydrobiopterin deficiency in eNOS uncoupling in hypertension, Reply to "Creatine synthesis demands the majority of the bioavailable L-arginine", (2015) J. Hyperten. 33(11):2368-70. PMCID: PMC4819245.
    [Abstract & Full Text]

  17. Youn JY, Zhou J, Cai H. Bone morphogenic protein 4 mediates NOX1-dependent eNOS uncoupling, endothelial dysfunction and COX2 induction in type 2 diabetes mellitus. (2015) Mol. Endocrinology. 29(8):1123-33. PMCID: PMC4518001.
    [Abstract & Full Text]

  18. Li Q, Cai H. Induction of cardioprotection by netrin-1 derived small peptides. Am. J. Physiol. Cell Physiol. 2015 Jul 15;309(2):C100-6. PMID: 25924621
    [Abstract & Full Text]

  19. Ping P, Gustafasson A, Bers D, Blatter L, Cai H, Jahangir A, Kelly D, Muoio D, O'Rourke B, Rabinovitch P, Trayanova N, Van Eyke J, Weiss JN, Wong R, Longacre LS. Harnessing the power of integrated mitochondrial biology and physiology: A special report on the NHLBI mitochondria in heart disease initiative. Circ Res. 2015 Jul 17;117(3):234-8. PMID: 26185209
    [Abstract & Full Text]

  20. Li Q, Cai H. ANO1 taking center stage: Blood pressure regulation in SHRs. Editorial comments on "Overexpression of ANO1/TMEM16A, an arterial Ca2+-activated Cl- channel, contributes to spontaneous hypertension". J. Mol. Cell. Cardiol. (2015) March 26;82:216-7. PMID: 25817885
    [Abstract & Full Text]

  21. Youn JY, Cai H. Fueling up the skeletal muscle to reduce obesity: A TrkB story. Editorial comments on "Activation of muscular TrkB by its small molecule agonist 7,8-dihydroxyflavone sex-dependently regulates energy metabolism in diet-induced obese mice". Chemistry and Biology, (2015) March 19;22(3):311-2 PMID: 25794433
    [Abstract & Full Text]

  22. Li Q, Youn JY, Cai H. Mechanisms and consequences of eNOS dysfunction in hypertension. J. Hyperten. 2015 Jun;33(6):1128-36.
    [Abstract & Full Text]

  23. Li Q, Wang P, Ye KQ, Cai H. Central role of SIAH inhibition in DCC-dependent cardioprotection provoked by netrin-1/NO. Proc. Natl. Acad. Sci. U. S. A. (2015) Jan 20;112(3):899-904. PMID: 25561546
    [Abstract & Full Text]

  24. Siu KL & Cai H. Circulating tetrahydrobiopterin as a novel biomarker for abdominal aortic aneurysm. (2014) Am. J. Physiol. Heart Circ. Physiol. 307(11):H1559-64; online first Sept. 26, 2014. PMID: 25260610
    [Abstract & Full Text]

  25. Siu KL, Lotz C, Ping PP, Cai H. Netrin-1 abrogates ischemia reperfusion induced mitochondrial dysfunction via attenuation of NOX4 activation and recoupling of NOS. (2014) J. Mol. Cell. Cardiol. 78:174-85; online July 24, 2014. PMID: 25066694
    [Abstract & Full Text]

  26. Zhang YX, Shimizu H, Siu KL, Mahajan A, Chen JN, and Cai H. NADPH oxidase 4 induces cardiac arrhythmic phenotype in zebrafish. (2014) J. Biol. Chem. 289(33):23200-8; online first June 24, 2014. PMID: 24962575
    [Abstract & Full Text]

  27. Bouhidel JOB,* Wang P,* Siu KL, Youn JY, Cai H. Netrin-1 improves post-injury cardiac function in vivo via DCC/NO-dependent preservation of mitochondrial function, while attenuating autophagy. (2014) BBA Mol. Basis of Disease 1852(2):277-89; online first June 10, 2014. *The authors contribute equally to this study. PMID: 24928309
    [Abstract & Full Text]

  28. Siu KL, Miao XN, Cai H. Recoupling of eNOS with folic acid prevents abdominal aortic aneurysm formation in angiotensin II infused apolipoprotein E null mice. (2014) PLOS One 9(2):e88899; online first Feb 2014
    [Abstract & Full Text]

  29. Youn JY, Siu KL, Lob HE, Itani H, Harrison DG, Cai H. Role of vascular oxidative stress in obesity. (2014) Diabetes 63(7):6344-55; online first Feb 2014 highlighted article with editorial
    [Abstract & Full Text]

  30. Bouhidel JOB, Wang P, Li Q, Cai H. Pharmacological postconditioning treatment of myocardial infarction with netrin-1. (2014) Frontiers in Bioscience (Landmark Edition) 19:566-570, PMCID: PMC4053198
    [Abstract & Full Text]

  31. Youn JY, Siu KL, Li Q, Harrison DG, Cai H. Oxidase interaction in cardiovascular disease; in System Biology of Oxidative Stress and Antioxidants. (2013) Editor Laher I, Springer, Chapter 37, 849-76.
    [Abstract & Full Text]

  32. Li Q, Youn JY, Cai H. Role of eNOS uncoupling in hypertension. (2013) Chinese Journal of Hypertension 21(12): 1105-9

  33. Youn JY, Zhang J, Zhang YX, Chen HZ, Liu DP, Ping PP, Weiss JN, Cai H. Oxidative stress in atrial fibrillation: An emerging role of NADPH oxidase. (2013) J. Mol. Cell. Cardiol. 62:72-9. PMCID: PMC3735724
    [Abstract & Full Text]

  34. Youn JY, Gao L, Zhang J, Cai H. The p47phox and NOXO1-dependent activation of NOX1 mediates eNOS uncoupling and endothelial dysfunction in diabetes. (2012) Diabetologia. 55(7):2069-79. PMCID: PMC3694990
    [Abstract & Full Text]

  35. Youn JY, Nguyen A, Chen P, Cai H. Inhibition of XO or NOX attenuates DES-induced NO deficiency without affecting its effect on LNCaP cell apoptosis and invasion. (2012) Clinical Sci. 123(8):509-18. PMCID: PMC3675905
    [Abstract & Full Text]

  36. Youn JY, Blair J, Wang T, Laude K, Oak JH, McCann LA, Harrison DG, Cai H. Endothelium-specific sepiapterin reductase deficiency in DOCA-salt hypertension. (2012) Am. J. Physiol. Heart Circ. Physiol. 302(11):H2243-9.
    [Abstract & Full Text]

  37. Zhang J, Youn JY, Kim AY, Gao L, Ngo D, Chen P, Ramire RJ, Mahajan A, Cai H. NOX4-dependent hydrogen peroxide production in human atrial fibrillation and HL-1 atrial cells: Relationship to hypertension. (2012) Frontiers in Physiology 3:104-114
    [Abstract & Full Text]

  38. Li J, Umar S, Iorga A, Youn JY, Wang Y, Regitz-Zagrosek V, Cai H, Eghbali M. Cardiac vulnerability to ischemia/reperfusion injury drastically increases during late pregnancy. (2012) Basic Res. Cardiol. 107: 271- online first May 21
    [Abstract & Full Text]

  39. Li J, Iorga A, Youn JY, partow-Navid R, Umar S, Cai H, Eghbali M. Intralipid, a clinically safe compound, protects the heart against ischemia reperfusion injury more efficiently than cyclosporine-A. Anesthesiology (2012) 117(4):836-46
    [Abstract & Full Text]

  40. Zhang J, Lin A, Powers J, Lotz C, Liem D, Lau E, Wang D, Deng N, Korge P, Zong N, Cai H, Weiss JN, Ping PP. Mitochondrial proteome design: from molecular identity to pathophysiological regulation. (2012) J. Gen. Physiol. 139(6):395-406.
    [Abstract & Full Text]

  41. Siu KL, Gao L, Cai H. Characterization of eNOS uncoupling in vivo and possible cause of H4B insensitivity in vitro: Reply to the Letter to the Editor "Tetrahydrobiopterin and endothelial nitric oxide synthase uncoupling" by Tsikas et al. (2011) Hypertension online first Dec 2011

  42. Gao L*, Siu KL*, Chalupsky K, Nguyen A, Chen P, Weintraub NL, Galis Z, Cai H. Role of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation: Treatment with folic acid. (2011) Hypertension. 59(1):158-66. *The authors contribute equally to this study. Collected and evaluated by faculty 1000 to be in the top 2% of biology and medicine. PMCID: PMC3668799
    [Abstract & Full Text]

  43. Zhou S, Chen HZ, Wan YZ, Zhang QJ, Wei YS, Huang S, Liu JJ, Lu YB, Zhang ZQ, Yang RF, Zhang R, Cai H, Liu DP, Liang CC. Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction. Circ Res (2011) Sept 109(6):639-48.
    [Abstract & Full Text]

  44. Zhang J, Cai H. Netrin-1 prevents ischemia/reperfusion-induced myocardial infarction via a DCC/ERK1/2/eNOSs1177/NO/DCC feed-forward mechanism. J. Mol. Cell. Cardiol. (2010) Jun;48(6):1060-70.
    [Abstract & Full Text]

  45. Oak JH, Youn JY, Cai H. Aminoguanidine inhibits aortic hydrogen peroxide production, VSMC NOX activity and hypercontractility in diabetic mice. Cardiovasc. Diabetology (2009) Dec 30;8:65.
    [Abstract & Full Text]

  46. Shuvaev VV, Christofidou-Solomidou M, Bhora F, Laude K, Cai H, Dikalov S, Arguiri E, Solomides CC, Albelda SM, Harrison D, Muzykantov VR. Targeted detoxification of selected reactive oxygen species in the vascular endothelium. J Pharmacol Exp Ther. (2009) Aug 19;331(2):404-11.
    [Abstract & Full Text]

  47. Gao L, Chalupsky K, Stefani E, Cai H. Mechanistic Insights into Folic Acid-dependent Vascular Protection: Dihydrofolate reductase-mediated Reduction in Oxidant Stress in Endothelial Cells and Angiotensin II-Infused Mice. A Novel HPLC-based Fluorescent Assay for DHFR Activity. J. Mol Cell Cardiol. (2009) Dec;47(6):752-60.
    [Abstract & Full Text]

  48. Zhuo ML, Huang Y, Chen JZ, Sun LH, Yang RF, Chen HZ, Lv X, Li HL, Wei YS, Liu G, Zhang R, Ma TM, Cai H, Hui RT, Liu DP, Liang CC. Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in mice. Cardiovasc Res. (2009) Nov 1;84(2):292-9.
    [Abstract & Full Text]

  49. Gao L, Pung YF, Zhang J, Chen P, Wang T, Li M, Meza M, Toro L, Cai H. Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability. Am. J. Physiol. Heart Circ. Physiol. (2009) Jul;297(1):H331-9.
    [Abstract & Full Text]

  50. Lu G, Sun H, She P, Youn JY, Warburton S, Ping P, Vondriska TM, Cai H, Lynch CJ, Wang Y. Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells. J Clin Invest. (2009) June 1; 119(6):1678-1687.
    [Abstract & Full Text]

  51. Youn JY, Wang T, Cai H. An Ezrin/Calpain/PI3K/AMPK/AKT/eNOSs1179 Signaling Cascade Mediating VEGF-dependent Endothelial Nitric Oxide Production. Circ. Res. (2009);104:50-59
    [Abstract & Full Text]

  52. Zhang QJ, Wang Z, Chen HZ, Zhou S, Zheng W, Liu G, Wei YS, Cai H, Liu DP, Liang CC. Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovasc Res. (2008) Nov 1;80(2):191-9.
    [Abstract & Full Text]

  53. Cai H, Liu DP, Garcia JG. CaM kinase II-dependent pathophysiological signaling in endothelial cells. Cardiovasc. Res. (2008) Jan;77(1):30-4.
    [Abstract & Full Text]

  54. Cai H, Dikalov S, Griendling KK, Harrison DG. Detection of reactive oxygen species and nitric oxide in vascular cells and tissues: comparison of sensitivity and specificity. Methods Mol Med (2007);139:293-311.
    [Abstract & Full Text]

  55. Li HL, Zhou ML, Wang D, Wang AB, Cai H, Sun LH, Yang Q, Huang Y, Wei YS, Liu DP, Liang CC. Targeted cardiac overexpression of A20 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction. Circulation (2007) Apr 10;115(14):1885-94.
    [Abstract & Full Text]

  56. Oak JH, Cai H. Attenuation of angiotensin II signaling recouples eNOS and inhibits non-endothelial NOX activity in diabetic mice. Diabetes (2007) Jan 56(1):118-126
    [Abstract & Full Text]

  57. Zhang G, Zhang F, Muh, R, Yi F, Chalupsky K, Cai H, Li PL. Autocrine/paracrine pattern of superoxide production through NAD(P)H oxidase in coronary arterial myocytes. Am. J. Physiol. Heart Circ. Physiol. (2007) Jan; 292(1): H483-95
    [Abstract & Full Text]

  58. Nguyen A, Cai H. Netrin-1 induces angiogenesis via a DCC-dependent ERK1/2-eNOS feed-forward mechanism. Proc Natl Acad Sci U S A. (2006) Track II, Apr 25;103(17):6530-5
    [Abstract & Full Text]

  59. Cai H. Potassium channel as endothelial mechanosensor and modulator of NAD(P)H oxidase: new mechanism for flow-mediated vasoprotection. (2006) Am J Physiol. Cell Physiol. Jan;290(1):C35-6
    [Full Text]

  60. Menshikov M, Plekhanova O, Cai H, Chalupsky K, Parfyonova Y, Bashtrikov P, Tkachuk V, Berk BC. Urokinase stimulates vascular smooth muscle proliferation via redox-sensitive pathways. (2006) Arterioscler. Thromb. Vasc. Biol. 26(4):801-7
    [Abstract & Full Text]

  61. Cai H. Hydrogen peroxide regulation of endothelial function: Origins, mechanisms and consequences. (2005) Cardiovasc. Res. 68(1):26-36
    [Abstract & Full Text]

  62. Chalupsky K & Cai H. Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of eNOS. Proc Natl Acad Sci U S A. Track II (2005) 102(25):9056-61
    [Abstract & Full Text]

  63. Cai H. NAD(P)H oxidase-dependent self-propagation of hydrogen peroxide and vascular disease. (2005) Circ. Res. 96(8): 818-22
    [Abstract & Full Text]

  64. Nakagawa K, Oak JH, Higuchi O, Tsuzuki T, Oikawa S, Otani H, Mune M, Cai H, Miyazawa T. Ion-trap tandem mass spectrometric analysis of Amadori-glycated phosphatidylethanolamine in human plasma with or without diabetes. (2005) J Lipid Res. Nov;46(11):2514-24.
    [Abstract & Full Text]

  65. McNally JS, Saxena A, Cai H, Dikalov S, Harrison DG. Regulation of xanthine oxidoreductase protein expression by hydrogen peroxide and calcium. Arterioscler Thromb Vasc Biol. (2005) Aug;25(8):1623-8.
    [Abstract & Full Text]

  66. Laude K, Cai H, Fink B, Hoch N, Weber DS, McCann L, Kojda G, Fukai T, Schmidt HH, Dikalov S, Ramasamy S, Gamez G, Griendling KK, Harrison DG. Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice. (2005) Am J Physiol Heart Circ Physiol. 288(1):H7-12
    [Abstract & Full Text]

  67. Nguyen A, Chen P, Cai H. Role of CaMKII in hydrogen peroxide activation of ERK1/2, p38 MAPK, HSP27 and actin reorganization in endothelial cells. (2004) FEBS Lett. 13;572(1-3):307-13
    [Abstract & Full Text]

  68. Searles CD, Ide L, Davis ME, Cai H, Weber M. Actin cytoskeleton organization and posttranscriptional regulation of endothelial nitric oxide synthase during cell growth. (2004) Circ. Res. 95(5):488-95
    [Abstract & Full Text]

  69. Cai H, McNally JS, Weber M, Harrison DG. Oscillatory shear stress regulation of endothelial cellsnitric oxide synthase requires intracellular hydrogen peroxide and CaMKII. (2004) J. Mol. Cell. Cardiol. 37:121-125
    [Abstract & Full Text]

  70. Harrison DG & Cai H. Endothelium control of vasomotion and nitric oxide production. (2003) Cardiology Clinics 21:289-302.
    [Review]

  71. Cai H, Griendling KK, Harrison DG. The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular disease. (2003) Trends in Pharmacological Science, 24:471-8.
    [Abstract & Full Text]

  72. Harrison DG, Cai H, Landmesser U, Griendling KK,. Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease. (2003) The Journal of the Renin-Angiotensin-Aldosterone System 4:51-61.
    [Abstract]

  73. Davis ME, Cai H, McCann L, Fukai T, Harrison DG. Role of c-Src in regulation of endothelial nitric oxide synthase expression during exercise training. (2003) Am. J. Physiol. Heart Circ. Physiol. 284:H1449-H1453.
    [Abstract & Full Text]

  74. Cai H, Li Z, Davis ME, Kanner W, Harrison DG, Dudley SC. Akt-dependent phosphorylation of serine 1179 and MEK/ERK 1/2 cooperatively mediates the activation of endothelial nitric oxide synthase by hydrogen peroxide. (2003) Molecular Pharmacology 63:325-331.
    [Abstract & Full Text]

  75. Cai H, Li Z, Dikalov S, Holland SM, Hwang J, Jo H, Dudley SC, Harrison DG. NAD(P)H oxidase-derived hydrogen peroxide mediates endothelial nitric oxide production of in response to angiotensin II. (2002) J. Biol. Chem. 277:48311-48317.
    [Abstract & Full Text]

  76. Cai H, Li Z, Goette A, Mera F, Honeycutt C, Feterik K, Dudley SC, , Harrison DG, Langberg JJ. Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation. Potential mechanisms for atrial thombosis and stroke. (2002) Circulation 106:2854-2858.
    [Abstract & Full Text]

  77. Landmesser U, Cai H, Dikalov S, McCann L, Hwang J, Jo H, Holland SM, Harrison DG. Role of p47phox in vascular oxidative stress and hypertension caused by angiotensin II. (2002) Hypertension 40:511-515.
    [Abstract & Full Text]

  78. Davis ME, Cai H, Drummond GR, Harrison DG. Shear Stress Regulates Endothelial Nitric Oxide Synthase Expression Through c-Src by Divergent Signaling Pathways. (2001) Circ. Res. 89:1073-1080.
    [Abstract & Full Text]

  79. Cai H, Davis ME, Drummond GR, Harrison DG. Induction of endothelial NO synthase by hydrogen peroxide via a Ca2+/camodulin-dependent protein kinase II/janus kinase 2-dependent pathway. (2001) Arterioscler Thromb Vasc Biol. 21:1571-1576.
    [Abstract & Full Text]

  80. Cai H & Harrison DG. Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress. (2000) Cir. Res. 87:840-844.
    [Abstract & Full Text]

  81. Chan DK, Mellick G, Cai H, Wang XL, Ng PW, Pang CP, Woo J, Kay R. The alpha-synuclein gene and Parkinson disease in a Chinese population. (2000) Arch Neurol. Apr;57(4):501-3
    [Abstract & Full Text]

  82. Drummond GR, Cai H, Davis ME, Ramasamy S, Harrison DG. Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide. (2000) Circ. Res. 86:347-354.
    [Abstract & Full Text]

  83. Cai H, Wang XL, Wilcken DE. Genetic polymorphism of heparan sulfate proteoglycan (perlecan, HSPG2), lipid profiles and coronary artery disease in the Australian population. (2000) AtherosclerosisJan;148(1):125-9
    [Abstract & Full Text]

  84. Wang XL, Duarte N, Cai H, Adachi T, Sim AS, Cranney G, Wilcken DE. Relationship between total plasma homocysteine, polymorphisms of homocysteine metabolism related enzymes, risk factors and coronary artery disease in the Australian hospital-based population. (1999) AtherosclerosisSep;146(1):133-40
    [Abstract & Full Text]

  85. Cai H, Duarte N, Wilcken DEL, Wang XL. NADH/NADPH oxidase p22 phox C242T polymorphism and coronary artery disease in the Australian population. (1999) Eur. J. Clin. Invest 29:744-748.
    [Abstract]

  86. Cai H, Wilcken DEL, Wang XL. The Glu298® Asp (984G® T) mutation at exon 7 of the endothelial nitric oxide synthase gene and coronary artery disease. (1999) J. Mol. Med. 77:511-514.
    [Abstract & Full Text]

  87. Wang XL, Duarte N, Cai H, Sim AS, Cranney G, Wilcken DEL. Relationship between total plasma homocysteine, polymorphisms of homocysteine metabolism related enzymes, risk factors and coronary artery disease in the Australian hospital-based population. (1999) Atherosclerosis 146:133-140.
    [Abstract & Full Text]

  88. Wang XL, Cai H, Cranney G, Wilcken DE. The frequency of a common mutation of the methionine synthase gene in the Australian population and its relation to smoking and coronary artery disease. (1998) J Cardiovasc RiskOct-Dec;5(5-6):289-95
    [Abstract & Full Text]

  89. Cai H, Wang X, Colagiuri S, Wilcken DE. Methionine synthase D919G mutation in type 2 diabetes and its relation to vascular events. (1998) Diabetes Care Oct;21(10):1774-5.
    [Abstract & Full Text]

  90. Cai H, Wang XL, Colagiuri S, Wilcken DEL. A common Glu298R Asp (894GR T) mutation at exon 7 of the endothelial nitric oxide synthase gene and vascular complications in type 2 diabetes. (1998) Diabetes Care Dec;21(12):2195-2196.
    [Abstract & Full Text]


Invited Book Chapters:

  1. Youn JY, Siu KL, Li Q, Harrison DG, Cai H. Oxidase interaction in cardiovascular disease; in System Biology of Oxidative Stress and Antioxidants. (2013) Editor Laher I, Springer, Chapter 37, 849-76.
    [Abstract & Full Text]

  2. Gao L, Laude K, Cai H. Mitochondrial Pathophysiology, Reactive Oxygen Species, and Cardiovascular Diseases. Veterinary Clinics of North America: Small Animal Practice; (2008) 38(1):137-55, vi.
    [Abstract & Full Text]

  3. Cai H, Dikalov S. Griendling KK, Harrison DG. Detection of reactive oxygen species and nitric oxide in vascular cells: Comparison of sensitivity and specificity. In Vascular Biology Protocols, Editors: N Sreejaya and Ren J, Methods in Molecular Medicine, Humana Press Inc., New York, (2007), pg 293-314
    [Full Text]